Abstract
Guatemala has an accelerating HIV rate, where prevalence is three times higher among indigenous than nonindigenous, comprising 21% of all cases. Vulnerability is exacerbated by high poverty, low literacy, and poor access to testing and treatment options. This study develops a community-engaged HIV prevention campaign plan for the Mayan town of Santiago Atitlán. The PEN-3 model of cultural sensitivity frames this formative research project. Assessment domains of the PEN-3 model (Cultural empowerment and Relationships & expectations) identify culturally relevant factors affecting HIV prevention behaviours. The Cultural identity domain is utilized to identify entry points enhancing cultural acceptance and efficacy.