Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Nathan P Coussens; G. Sitta Sittampalam; Rajarshi Guha; Kyle Brimacombe; Abigail Grossman; Thomas D. Y Chung; Jeffrey R Weidner; Terry Riss; O. Joseph Trask; Douglas Auld; Jayme L Dahlin; Viswanath Devanaryan; Timothy L Foley; James McGee; Steven D Kahl; Stephen C Kales; Michelle Arkin; Jonathan Baell; Bruce Bejcek; Neely Gal‐Edd; Marcie Glicksman; Joseph V Haas; Philip W Iversen; Marilu Hoeppner; Stacy Lathrop; Eric Sayers; Hanguan Liu; Bart Trawick; Julie McVey; Vance P Lemmon; Zhuyin Li; Owen McManus; Lisa Minor; Andrew Napper; Mary Jo Wildey; Robert Pacifici; William W Chin; Menghang Xia; Xin Xu; Madhu Lal‐Nag; Matthew D Hall; Sam Michael; James Inglese; Anton Simeonov; Christopher P Austin

doi:10.1111/cts.12570

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Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Journal article

Open access

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Nathan P Coussens, G. Sitta Sittampalam, Rajarshi Guha, Kyle Brimacombe, Abigail Grossman, Thomas D. Y Chung, Jeffrey R Weidner, Terry Riss, O. Joseph Trask, Douglas Auld, …

Clinical and translational science, Vol.11(5), pp.461-470

2018-09

DOI: https://doi.org/10.1111/cts.12570

PMCID: PMC6132369

PMID: 29877628

Abstract

Tutorial

The Assay Guidance Manual (AGM) is an e Book of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists .

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.196 Micro & Long Noncoding RNA; 1.196.1705 RNAi
Web Of Science research areas: Medicine, Research & Experimental
ESI research areas: Clinical Medicine

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Title: Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
Creators: Nathan P Coussens - National Institutes of Health
G. Sitta Sittampalam - National Institutes of Health
Rajarshi Guha - National Institutes of Health
Kyle Brimacombe - National Institutes of Health
Abigail Grossman - National Institutes of Health
Thomas D. Y Chung - Sanford Burnham Prebys Medical Discovery Institute
Jeffrey R Weidner - LLC
Terry Riss - Promega Corporation
O. Joseph Trask - PerkinElmer, Inc., Waltham
Douglas Auld - Novartis Institutes for Biomedical Research
Jayme L Dahlin - Brigham and Women's Hospital
Viswanath Devanaryan - Charles River Laboratories
Timothy L Foley - Pfizer Worldwide Research and Development
James McGee - Eli Lilly and Company
Steven D Kahl - Eli Lilly and Company
Stephen C Kales - National Institutes of Health
Michelle Arkin - University of California
Jonathan Baell - Monash University
Bruce Bejcek - Western Michigan University
Neely Gal‐Edd - MacroGenics, Inc., Rockville
Marcie Glicksman - Orig3n, Boston
Joseph V Haas - Eli Lilly and Company
Philip W Iversen - Eli Lilly and Company
Marilu Hoeppner - National Center for Biotechnology Information
Stacy Lathrop - National Center for Biotechnology Information
Eric Sayers - National Center for Biotechnology Information
Hanguan Liu - National Center for Biotechnology Information
Bart Trawick - National Center for Biotechnology Information
Julie McVey - National Center for Biotechnology Information
Vance P Lemmon - University of Miami Miller School of Medicine
Zhuyin Li - Lead Discovery and Optimization
Owen McManus - Q‐State Biosciences
Lisa Minor - In Vitro Strategies, LLC
Andrew Napper - FLX Bio, Inc., San Francisco
Mary Jo Wildey - Merck Research Laboratories
Robert Pacifici - Inc./CHDI Foundation, Inc., Los Angeles
William W Chin - Harvard Medical School, Boston
Menghang Xia - National Institutes of Health
Xin Xu - National Institutes of Health
Madhu Lal‐Nag - National Institutes of Health
Matthew D Hall - National Institutes of Health
Sam Michael - National Institutes of Health
James Inglese - National Institutes of Health
Anton Simeonov - National Institutes of Health
Christopher P Austin - National Institutes of Health
Publication Details: Clinical and translational science, Vol.11(5), pp.461-470
Publisher: John Wiley and Sons Inc; Hoboken
Grant note: Intramural Research Program of the NIH NCATS Division of Pre‐Clinical Innovation Intramural Program NIGMS R13; 5U13MH088095‐02 / National Library of Medicine
Academic Unit: Miller School of Medicine; UMMG Dept of Neurological Surgery; Miami Project to Cure Paralysis
Language: English
Resource Type: Journal article
PMID: 29877628
PMCID: PMC6132369
Record Identifier: 991031576152802976