Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region

Kenneth J Holroyd; Laura C Martinati; Elisabetta Trabetti; Titia Scherpbier; Scott M Eleff; Attilio L Boner; Pier Franco Pignatti; Matthew B Kiser; Carl R Dragwa; Frank Hubbard; Christine D Sullivan; Luigi Grasso; Carol J Messler; Minxue Huang; Ying Hu; Nicholas C Nicolaides; Kenneth H Buetow; Roy C Levitt

doi:10.1006/geno.1998.5445

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Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region

Journal article

Peer reviewed

Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region

Kenneth J Holroyd, Laura C Martinati, Elisabetta Trabetti, Titia Scherpbier, Scott M Eleff, Attilio L Boner, Pier Franco Pignatti, Matthew B Kiser, Carl R Dragwa, Frank Hubbard, …

Genomics (San Diego, Calif.), Vol.52(2), pp.233-235

1998-09-01

DOI: https://doi.org/10.1006/geno.1998.5445

PMID: 9782093

Abstract

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P= 0.000057) or asthma (P= 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.44 Asthma
Web Of Science research areas: Biotechnology & Applied Microbiology; Genetics & Heredity
ESI research areas: Molecular Biology & Genetics

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Title: Asthma and Bronchial Hyperresponsiveness Linked to the XY Long Arm Pseudoautosomal Region
Creators: Kenneth J Holroyd - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Laura C Martinati - Department of Pediatrics, University of Verona, Verona, Italy
Elisabetta Trabetti - Institute of Biology and Genetics, University of Verona, Verona, Italy
Titia Scherpbier - Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111
Scott M Eleff - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, 21287
Attilio L Boner - Department of Pediatrics, University of Verona, Verona, Italy
Pier Franco Pignatti - Institute of Biology and Genetics, University of Verona, Verona, Italy
Matthew B Kiser - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Carl R Dragwa - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Frank Hubbard - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Christine D Sullivan - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Luigi Grasso - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Carol J Messler - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Minxue Huang - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Ying Hu - Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111
Nicholas C Nicolaides - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Kenneth H Buetow - Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111
Roy C Levitt - Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462
Publication Details: Genomics (San Diego, Calif.), Vol.52(2), pp.233-235
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Anesthesiology
Language: English
Resource Type: Journal article
PMID: 9782093
Record Identifier: 991031613747502976