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Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors
Journal article   Peer reviewed

Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors

Yen Ting Chen, Tomas Vojkovsky, Xingang Fang, Jennifer R. Pocas, Wayne Grant, Amiee M. W. Handy, Thomas Schroeter, Philip LoGrasso, Thomas D. Bannister, Yangbo Fang, …
MedChemComm, Vol.2(1), pp.73-75
2011-01-01
DOI: https://doi.org/10.1039/c0md00194e

Abstract

Biochemistry & Molecular Biology Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Rho kinase (ROCK) is currently investigated as a target for various diseases such as glaucoma and spinal cord injury. Herein, we report the asymmetric synthesis of chroman 1, a highly potent ROCK inhibitor, and its analogs. The inhibitory properties of these compounds for ROCK-II and a selected set of highly homologous kinases are also discussed.

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12 Times Cited - Web of Science

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Citation topics
1 Clinical & Life Sciences
1.96 Cell Biology
1.96.224 Integrins
Web Of Science research areas
Biochemistry & Molecular Biology
Chemistry, Medicinal
ESI research areas
Pharmacology & Toxicology

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#3 Good Health and Well-Being

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