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Aβ Puts the Alpha in Synuclein
Journal article   Open access

Aβ Puts the Alpha in Synuclein

C. Cook and L. Petrucelli
Neuron, Vol.105(2), pp.205-206
2020
DOI: https://doi.org/10.1016/j.neuron.2020.01.001
PMID: 31972141

Abstract

alpha-Synuclein Alzheimer Disease Amyloid beta-Peptides Animals Lewy Bodies Lewy Body Disease Mice Plaque, Amyloid alpha synuclein amyloid beta protein amyloid beta protein[1-42] amyloid precursor protein tau protein alpha synuclein amyloid beta protein Alzheimer disease amyloid plaque Article bioaccumulation comorbidity diffuse Lewy body disease disease association disease burden disease course histopathology human nerve degeneration neuropathology nonhuman Parkinson disease priority journal protein function protein phosphorylation Alzheimer disease animal diffuse Lewy body disease Lewy body mouse
Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are characterized pathologically by aberrant protein accumulation, such as Aβ or α-synuclein deposition. In this issue of Neuron, Bassil et al. (2020) observed an exacerbation of α-syn pathology in the presence of Aβ plaques in vivo, with comorbid pathologies associated with greater neurodegeneration. © 2020 Elsevier Inc.
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