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B cell development leads off with a base hit: dU:dG mismatches in class switching and hypermutation
Journal article   Open access  Peer reviewed

B cell development leads off with a base hit: dU:dG mismatches in class switching and hypermutation

Gregory S Lee, Vicky L Brandt and David B Roth
Molecular cell, Vol.16(4), pp.505-508
2004-11-19
DOI: https://doi.org/10.1016/j.molcel.2004.11.008
PMID: 15546611

Abstract

Uracil-DNA Glycosidase B-Lymphocytes - enzymology RNA Editing Humans Base Pair Mismatch - immunology Models, Immunological Animals B-Lymphocytes - immunology Cytidine Deaminase - metabolism DNA Repair Somatic Hypermutation, Immunoglobulin - genetics Immunoglobulin Class Switching - genetics B-Lymphocytes - metabolism DNA Glycosylases - metabolism
The mechanisms underlying somatic hypermutation (SHM) and class switch recombination (CSR) have been the subject of much debate. Recent studies from the Neuberger and Honjo labs have lent insight into these distinct processes, and we discuss a new, comprehensive model for how AID, uracil DNA glycosylase (UNG) and the mismatch repair system function in both SHM and CSR.
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https://doi.org/10.1016/j.molcel.2004.11.008View
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Citation topics
1 Clinical & Life Sciences
1.6 Immunology
1.6.452 Somatic Hypermutation
Web Of Science research areas
Biochemistry & Molecular Biology
Cell Biology
ESI research areas
Molecular Biology & Genetics

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