B cell function and influenza vaccine responses in healthy aging and disease

Daniela Frasca; Bonnie B Blomberg

doi:10.1016/j.coi.2014.05.008

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B cell function and influenza vaccine responses in healthy aging and disease

Journal article

Open access

Peer reviewed

B cell function and influenza vaccine responses in healthy aging and disease

Daniela Frasca and Bonnie B Blomberg

Current opinion in immunology, Vol.29(1), pp.112-118

2014-08

DOI: https://doi.org/10.1016/j.coi.2014.05.008

PMCID: PMC4331104

PMID: 24934648

Abstract

Cardiovascular Diseases - immunology

HIV Infections - immunology

Aging - immunology

Animals

B-Lymphocytes - immunology

Influenza Vaccines - immunology

Diabetes Mellitus, Type 2 - immunology

Humans

Antibodies, Viral - immunology

Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have addressed the identification of immune biomarkers able to monitor or predict a protective humoral immune response to the vaccine. In this review, we summarize these data, with emphasis on the effects of aging on influenza vaccine-specific B cell responses in healthy individuals and patients with Type-2 Diabetes, HIV and cardiovascular diseases.

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https://doi.org/10.1016/j.coi.2014.05.008View

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Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.126 Influenza
Web Of Science research areas: Immunology
ESI research areas: Immunology

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Details

Title: B cell function and influenza vaccine responses in healthy aging and disease
Creators: Daniela Frasca - University of Miami Miller School of Medicine, Miami, FL 33136, USA
Bonnie B Blomberg - University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: bblomber@med.miami.edu
Publication Details: Current opinion in immunology, Vol.29(1), pp.112-118
Publisher: England
Grant note: R37 AG023717 / NIA NIH HHS R21 AI096446 / NIAID NIH HHS AG042826 / NIA NIH HHS AG032576 / NIA NIH HHS R01 AG023717 / NIA NIH HHS AI096446 / NIAID NIH HHS R56 AG032576 / NIA NIH HHS AG023717 / NIA NIH HHS R01 AG032576 / NIA NIH HHS R21 AG042826 / NIA NIH HHS
Academic Unit: Miller School of Medicine; Microbiology and Immunology Research
Language: English
Resource Type: Journal article
PMID: 24934648
PMCID: PMC4331104
Record Identifier: 991031559859502976