BANFF 2022 PANCREAS TRANSPLANTATION MULTIDISCIPLINARY REPORT: Refinement of guidelines for TCMR, AMR, islet and non-rejection pathologies. Assessment of duodenal cuff biopsies and non-invasive diagnostic methods

Cinthia B. Drachenberg; Maike Buettner-Herold; Pedro Ventura Aguiar; Catherine Horsfield; Alexei V. Mikhailov; John C. Papadimitriou; Surya V. Seshan; Marcelo Perosa; Ugo Boggi; Pablo Uva; Michael Rickels; Krzyztof Grzyb; Lois Arend; Miriam Cuatrecasas; Maria Fernanda Toniolo; Alton B. Farris; Karine Renaudin; Lizhi Zhang; Candice Roufousse; Angelika Gruessner; Rainer Gruessner; Raja Kandaswamy; Steven White; George Burke; Diego Cantarovich; Ronald F. Parsons; Matthew Cooper; Yogish C. Kudva; Aleksandra Kukla; Abdolreza Haririan; Sandesh Parajuli; Juan Francisco Merino-Torres; Maria Argente-Pla; Raphael Meier; Ty Dunn; Richard Ugarte; Joseph Sushil Rao; Fabio Vistoli; Robert Stratta; Jon Odorico

doi:10.1016/j.ajt.2023.10.011

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BANFF 2022 PANCREAS TRANSPLANTATION MULTIDISCIPLINARY REPORT: Refinement of guidelines for TCMR, AMR, islet and non-rejection pathologies. Assessment of duodenal cuff biopsies and non-invasive diagnostic methods

Journal article

Peer reviewed

BANFF 2022 PANCREAS TRANSPLANTATION MULTIDISCIPLINARY REPORT: Refinement of guidelines for TCMR, AMR, islet and non-rejection pathologies. Assessment of duodenal cuff biopsies and non-invasive diagnostic methods

Cinthia B. Drachenberg, Maike Buettner-Herold, Pedro Ventura Aguiar, Catherine Horsfield, Alexei V. Mikhailov, John C. Papadimitriou, Surya V. Seshan, Marcelo Perosa, Ugo Boggi, Pablo Uva, …

American journal of transplantation

2023-10-21

DOI: https://doi.org/10.1016/j.ajt.2023.10.011

PMID: 37871799

Appears in Miller School of Medicine - Latest Publications

Abstract

MVI

DGF

PTxBx

AMR

CIN

PNF

Igls criteria

T1DR

dd cf DNA

SPK

C4d

CD3

DSA

TCMR

Pakistan

CD68

dnDSA

PTA

HbA1c

The Banff pancreas working schema for diagnosis and grading of rejection is widely used for treatment guidance and risk stratification in centers that perform pancreas allograft biopsies. Since the last update, various studies have provided additional insight regarding the application of the schema and enhanced our understanding of additional clinicopathological entities. This update aims to clarify terminology and lesion description for T-cell mediated and antibody mediated allograft rejections, in both active and chronic forms. In addition, morphological and immunohistochemical tools are described to help distinguish rejection from non-rejection pathologies. For the first time, a clinicopathological approach to islet pathology in the early and late post-transplant periods is discussed. This update also includes a discussion and recommendations on the utilization of endoscopic duodenal donor cuff biopsies as surrogates for pancreas biopsies in various clinical settings. Finally, an analysis and recommendations on the use of donor derived cell free DNA for monitoring pancreas graft recipients is provided. This multidisciplinary effort assesses the current role of pancreas allograft biopsies, and offers practical guidelines that can be helpful to pancreas transplant practitioners as well as experienced pathologists and pathologists in training.

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Title: BANFF 2022 PANCREAS TRANSPLANTATION MULTIDISCIPLINARY REPORT: Refinement of guidelines for TCMR, AMR, islet and non-rejection pathologies. Assessment of duodenal cuff biopsies and non-invasive diagnostic methods
Creators: Cinthia B. Drachenberg - Department of Pathology University of Maryland School of Medicine, MD, USA
Maike Buettner-Herold - Friedrich-Alexander-Universität Erlangen-Nürnberg
Pedro Ventura Aguiar - Hospital Clínic de Barcelona
Catherine Horsfield - Guy's and St Thomas' NHS Foundation Trust
Alexei V. Mikhailov - New England Baptist Hospital
John C. Papadimitriou - Department of Pathology University of Maryland School of Medicine, MD, USA
Surya V. Seshan - Cornell University
Marcelo Perosa - Beneficência Portuguesa de São Paulo
Ugo Boggi - University of Pisa
Pablo Uva - Kidney/Pancreas Transplant Program. Instituto de Trasplantes y Alta Complejidad (ITAC – Nephrology). Buenos Aires, Argentina
Michael Rickels - Hospital of the University of Pennsylvania
Krzyztof Grzyb - Oslo University Hospital
Lois Arend - Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD
Miriam Cuatrecasas - Hospital Clínic de Barcelona
Maria Fernanda Toniolo - Centro de Diagnostico Patologico, Buenos Aires, Argentina
Alton B. Farris - Emory University School of Medicine
Karine Renaudin - Department of Pathology CHU – Hôtel Dieu, Nantes, France
Lizhi Zhang - Mayo Clinic
Candice Roufousse - Imperial College London
Angelika Gruessner - Department of Nephrology/Medicine, State University of New York, NY
Rainer Gruessner - Department of Surgery, State University of New York, NY
Raja Kandaswamy - University of Minnesota
Steven White - Department of Surgery, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, England, United Kingdom
George Burke - Miami Transplant Institute, Division of Kidney-Pancreas Transplantation, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL
Diego Cantarovich - Department of Nephrology CHU – Hôtel Dieu, Nantes, France
Ronald F. Parsons - Emory University School of Medicine
Matthew Cooper - Medical College of Wisconsin
Yogish C. Kudva - Mayo Clinic in Arizona
Aleksandra Kukla - Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN
Abdolreza Haririan - Department of Medicine, University of Maryland School of Medicine, MD
Sandesh Parajuli - University of Wisconsin School of Medicine and Public Health
Juan Francisco Merino-Torres - Universitat de València
Maria Argente-Pla - University Hospital La Fe, Health Research Institute La Fe. Spain
Raphael Meier - Department of Surgery, University of Maryland School of Medicine, MD
Ty Dunn - University of Pennsylvania
Richard Ugarte - Department of Medicine, University of Maryland School of Medicine, MD
Joseph Sushil Rao - University of Minnesota
Fabio Vistoli - University of Pisa
Robert Stratta - New England Baptist Hospital
Jon Odorico - University of Wisconsin School of Medicine and Public Health
Publication Details: American journal of transplantation
Publisher: Elsevier Inc
Grant note: CSL BehringCareDxImmucorEGenesisKamada Ltd
The 2022 Banff meeting received sponsorship from CSL Behring, CareDx, Immucor, eGenesis, and Kamada Ltd.
Academic Unit: Miller School of Medicine; Miami Transplant Institute; UMMG Department of Surgery
Language: English
Resource Type: Journal article
PMID: 37871799
Record Identifier: 991031945130202976