Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: a prospective study using functional and morphologic imaging

Manisha Bhutani; Baris Turkbey; Esther Tan; Neha Korde; Mary Kwok; Elisabet E. Manasanch; Nishant Tageja; Sham Mailankody; Mark Roschewski; Marcia Mulquin; Ashley Carpenter; Elizabeth Lamping; Alex R. Minter; Brendan M. Weiss; Esther Mena; Liza Lindenberg; Katherine R. Calvo; Irina Maric; Saad Z. Usmani; Peter L. Choyke; Karen Kurdziel; Ola Landgren; Carl Ola Landgren

doi:10.3109/10428194.2015.1090572

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Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: a prospective study using functional and morphologic imaging

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Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: a prospective study using functional and morphologic imaging

Manisha Bhutani, Baris Turkbey, Esther Tan, Neha Korde, Mary Kwok, Elisabet E. Manasanch, Nishant Tageja, Sham Mailankody, Mark Roschewski, Marcia Mulquin, …

Leukemia & lymphoma, Vol.57(5), pp.1114-1121

2016-05-03

DOI: https://doi.org/10.3109/10428194.2015.1090572

PMCID: PMC5576169

PMID: 26690712

Abstract

DCE-MRI

FDG

functional imaging

MGUS

multiple myeloma

NaF

PET/CT

smoldering myeloma

The incidence and importance of bone marrow involvement and/or early bone lesions in multiple myeloma (MM) precursor diseases is largely unknown. This study prospectively compared the sensitivity of several imaging modalities in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM. Thirty patients (10 each with MGUS, SMM and MM) were evaluated with skeletal survey, [ 18 F]FDG-PET/CT, [ 18 F]NaF-PET/CT and morphologic dynamic contrast enhanced (DCE)-MRI. An additional 16 SMM patients had skeletal surveys and FDG-PET/CT. Among MGUS patients, DCE-MRI found only one focal marrow abnormality; other evaluations were negative. Among 26 SMM patients, five (19%) were re-classified as MM based on lytic bone lesions on CT and six had unifocal or diffuse marrow abnormality. Among MM, marrow abnormalities were observed on FDG-PET/CT in 8/10 patients and on DCE-MRI in nine evaluable patients. Abnormal NaF uptake was observed only in MM patients with lytic lesions on CT, providing no additional clinical information.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.130 Lymphomas; 1.130.617 Multiple Myeloma
Web Of Science research areas: Hematology; Oncology
ESI research areas: Clinical Medicine

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Title: Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease: a prospective study using functional and morphologic imaging
Creators: Manisha Bhutani - Carolinas Healthcare System
Baris Turkbey - c Molecular Imaging Program , CCR, NCI, NIH , Bethesda , MD , USA ;
Esther Tan - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Neha Korde - Memorial Sloan Kettering Cancer Center
Mary Kwok - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Elisabet E. Manasanch - The University of Texas MD Anderson Cancer Center
Nishant Tageja - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Sham Mailankody - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Mark Roschewski - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Marcia Mulquin - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Ashley Carpenter - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Elizabeth Lamping - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Alex R. Minter - a Multiple Myeloma Section , Lymphoid Malignancies Branch, CCR, NCI, NIH , Bethesda , MD , USA ;
Brendan M. Weiss - University of Pennsylvania
Esther Mena - c Molecular Imaging Program , CCR, NCI, NIH , Bethesda , MD , USA ;
Liza Lindenberg - c Molecular Imaging Program , CCR, NCI, NIH , Bethesda , MD , USA ;
Katherine R. Calvo - g Hematology Section , DLM, CC, NIH , Bethesda , MD , USA.
Irina Maric - g Hematology Section , DLM, CC, NIH , Bethesda , MD , USA.
Saad Z. Usmani - Carolinas Healthcare System
Peter L. Choyke - c Molecular Imaging Program , CCR, NCI, NIH , Bethesda , MD , USA ;
Karen Kurdziel - c Molecular Imaging Program , CCR, NCI, NIH , Bethesda , MD , USA ;
Ola Landgren - Memorial Sloan Kettering Cancer Center
Carl Ola Landgren - Miller School of Medicine
Publication Details: Leukemia & lymphoma, Vol.57(5), pp.1114-1121
Publisher: Taylor & Francis
Academic Unit: UMMG Department of Medicine; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 26690712
PMCID: PMC5576169
Record Identifier: 991031713474402976