Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease

Carolina Abulafia; David Loewenstein; Rosie Curiel-Cid; Bárbara Duarte-Abritta; Stella M Sánchez; Daniel E Vigo; Mariana N Castro; Lucas J Drucaroff; Silvia Vázquez; Gustavo Sevlever; Charles B Nemeroff; Salvador M Guinjoan; Mirta F Villarreal

doi:10.1176/appi.neuropsych.17120355

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Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease

Journal article

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Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease

Carolina Abulafia, David Loewenstein, Rosie Curiel-Cid, Bárbara Duarte-Abritta, Stella M Sánchez, Daniel E Vigo, Mariana N Castro, Lucas J Drucaroff, Silvia Vázquez, Gustavo Sevlever, …

The journal of neuropsychiatry and clinical neurosciences, Vol.31(1), pp.25-36

2019

DOI: https://doi.org/10.1176/appi.neuropsych.17120355

PMID: 30305005

Abstract

Cognitive Disorders

Imaging Techniques

Alzheimer’s Disease

Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer's disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer's disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer's disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer's-relevant brain regions even at a relatively young age.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Clinical Neurology; Neurosciences; Psychiatry
ESI research areas: Neuroscience & Behavior

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Title: Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease
Creators: Carolina Abulafia - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
David Loewenstein - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Rosie Curiel-Cid - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Bárbara Duarte-Abritta - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Stella M Sánchez - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Daniel E Vigo - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Mariana N Castro - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Lucas J Drucaroff - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Silvia Vázquez - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Gustavo Sevlever - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Charles B Nemeroff - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Salvador M Guinjoan - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Mirta F Villarreal - From the Fleni Foundation, Buenos Aires (CA, BDA, SMS, MNC, LJC, SV, GS, SMG, MFV); the Institute for Biomedical Research, Pontifical Catholic University of Argentina, Buenos Aires (CA, DEV); the National Scientific and Technical Research Council, Buenos Aires (CA, SMS, DEV, MNC, LJD, SMG, MFV); the Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine (MNC, LJD, SMG); the Department of Physics, University of Buenos Aires (SMS, MFV); and the Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami (DL, RC, CBN)
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.31(1), pp.25-36
Publisher: United States
Academic Unit: Miller School of Medicine; Center on Aging; UMMG Dept of Psychiatry & Behavioral Sciences
Language: English
Resource Type: Journal article
PMID: 30305005
Record Identifier: 991031561928202976