CD8 + gamma-delta TCR + and CD4 + T cells produce IFN-γ at 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Patrícia C.C Neves; Richard A Rudersdorf; Ricardo Galler; Myrna C Bonaldo; Marlon Gilsepp Veloso de Santana; Philip A Mudd; Maurício A Martins; Eva G Rakasz; Nancy A Wilson; David I Watkins

doi:10.1016/j.vaccine.2010.09.090

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CD8 + gamma-delta TCR + and CD4 + T cells produce IFN-γ at 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Journal article

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CD8 + gamma-delta TCR + and CD4 + T cells produce IFN-γ at 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Patrícia C.C Neves, Richard A Rudersdorf, Ricardo Galler, Myrna C Bonaldo, Marlon Gilsepp Veloso de Santana, Philip A Mudd, Maurício A Martins, Eva G Rakasz, Nancy A Wilson and David I Watkins

Vaccine, Vol.28(51), pp.8183-8188

2010

DOI: https://doi.org/10.1016/j.vaccine.2010.09.090

PMCID: PMC3179417

PMID: 20939995

Abstract

Yellow fever vaccine

IFN-γ

Rhesus model

The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5–7) before the development of classical antigen-specific CD8 + and CD4 + T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8 + gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4 + T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.228 Virology - Tropical Diseases; 1.228.200 Dengue
Web Of Science research areas: Immunology; Medicine, Research & Experimental
ESI research areas: Immunology

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Title: CD8 + gamma-delta TCR + and CD4 + T cells produce IFN-γ at 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses
Creators: Patrícia C.C Neves - Vice-diretoria de Desenvolvimento Tecnológico, Bio-Manguinhos, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos 21040-360, Rio de Janeiro, Brazil
Richard A Rudersdorf - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706 USA
Ricardo Galler - Vice-diretoria de Desenvolvimento Tecnológico, Bio-Manguinhos, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos 21040-360, Rio de Janeiro, Brazil
Myrna C Bonaldo - Laboratório de Biologia Molecular de Flavivírus, IOC, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos 21040-360, Rio de Janeiro, Brazil
Marlon Gilsepp Veloso de Santana - Laboratório de Biologia Molecular de Flavivírus, IOC, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos 21040-360, Rio de Janeiro, Brazil
Philip A Mudd - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706 USA
Maurício A Martins - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706 USA
Eva G Rakasz - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706 USA
Nancy A Wilson - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706 USA
David I Watkins - Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706 USA
Publication Details: Vaccine, Vol.28(51), pp.8183-8188
Publisher: Elsevier Ltd
Academic Unit: UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 20939995
PMCID: PMC3179417
Record Identifier: 991031598081902976