Abstract
The 2015 Conference on Retroviruses and Opportunistic Infections (CROI) represents a forum that encompasses all facets of research on HIV/AIDS and its complications. CROI is a valuable venue for scientific and public health researchers, clinicians, policy makers, and community representatives to be updated on the latest advances in their specific areas of interest and beyond. CROI 2015 continued to surprise. New insights into the viral reservoirs that persist in the face of antiretroviral therapy were prominently featured, as were therapeutic approaches aimed at curtailing and eliminating persistent viral reservoirs in HIV-infected individuals. Basic science is providing surrogates that could be valuable in how viral reservoirs are measured and, ultimately, in how to gauge if they are being effectively eliminated.