Cardiac Failure 30 Years after Treatment Containing Anthracycline for Childhood Acute Lymphoblastic Leukemia

John M Goldberg; Rebecca E Scully; Stephen E Sallan; Steven E Lipshultz

doi:10.1097/MPH.0b013e3182532078

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Cardiac Failure 30 Years after Treatment Containing Anthracycline for Childhood Acute Lymphoblastic Leukemia

Journal article

Open access

Peer reviewed

Cardiac Failure 30 Years after Treatment Containing Anthracycline for Childhood Acute Lymphoblastic Leukemia

John M Goldberg, Rebecca E Scully, Stephen E Sallan and Steven E Lipshultz

Journal of pediatric hematology/oncology, Vol.34(5), pp.395-397

2012-07

DOI: https://doi.org/10.1097/MPH.0b013e3182532078

PMCID: PMC3380184

PMID: 22584777

Abstract

Heart failure

late-effects

cancer survivorship

In 1977, a 5-year-old girl diagnosed with acute lymphoblastic leukemia (ALL) was treated on DFCI Childhood ALL Protocol 77-01, receiving a cumulative doxorubicin dose of 465 mg/m 2 , cranial radiation, and other drugs. After being in continuous complete remission for 34 months, she developed heart failure (HF) and was treated with digoxin and furosemide. At 16, she was diagnosed and treated for dilated cardiomyopathy. Over the years she continued to have bouts of HF, which became less responsive to treatment. At 36, she received a heart transplant. Six months later, she stopped taking her medications and suffered a sudden cardiac death.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.219 Cancer Drugs; 1.219.1342 Cardiotoxicity
Web Of Science research areas: Hematology; Oncology; Pediatrics
ESI research areas: Clinical Medicine

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Title: Cardiac Failure 30 Years after Treatment Containing Anthracycline for Childhood Acute Lymphoblastic Leukemia
Creators: John M Goldberg - Department of Pediatrics, University of Miami Leonard M. Miller School of Medicine, Miami, FL
Rebecca E Scully - Department of Pediatrics, University of Miami Leonard M. Miller School of Medicine, Miami, FL
Stephen E Sallan - Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
Steven E Lipshultz - Department of Pediatrics, University of Miami Leonard M. Miller School of Medicine, Miami, FL
Publication Details: Journal of pediatric hematology/oncology, Vol.34(5), pp.395-397
Grant note: R01 CA127642-02 || CA / National Cancer Institute : NCI R13 HL087708-01 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-09 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-12 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL072705-04 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL078522-01 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL072705-05 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-08 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL072705-06 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL078522-02 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-11 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-07 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL072705-01 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL078522-04 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL078522-05 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 CA127642-01A1 || CA / National Cancer Institute : NCI R01 HL078522-03 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL072705-02 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-15 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-10 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-13 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 CA127642-03 || CA / National Cancer Institute : NCI R01 HL053392-05S1 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-06A1 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL072705-03 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-14 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-05S2 || HL / National Heart, Lung, and Blood Institute : NHLBI R01 HL053392-05 || HL / National Heart, Lung, and Blood Institute : NHLBI
Academic Unit: UMMG Department of Pediatrics
Language: English
Resource Type: Journal article
PMID: 22584777
PMCID: PMC3380184
Record Identifier: 991031575966302976