Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study

Lisa K Hornberger; Steven E Lipshultz; Kirk A Easley; Steven D Colan; Marcy Schwartz; Samuel Kaplan; Thomas J Starc; Nancy A Ayres; Wyman W Lai; Douglas S Moodie; Carol Kasten-Sportes; Stephen P Sanders; for the P

doi:10.1067/mhj.2000.109645

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Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study

Journal article

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Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study

Lisa K Hornberger, Steven E Lipshultz, Kirk A Easley, Steven D Colan, Marcy Schwartz, Samuel Kaplan, Thomas J Starc, Nancy A Ayres, Wyman W Lai, Douglas S Moodie, …

The American heart journal, Vol.140(4), pp.575-584

2000-10

DOI: https://doi.org/10.1067/mhj.2000.109645

PMCID: PMC4309555

PMID: 11011330

Abstract

Background This study was designed to determine if vertically transmitted HIV infection and maternal infection with HIV are associated with altered cardiovascular structure and function in utero. Methods Fetal echocardiography was performed in 173 fetuses of 169 HIV-infected mothers (mean gestational age, 33.0 weeks; SD = 3.7 weeks) at 5 centers. Biparietal diameter, femur length, cardiovascular dimensions, and Doppler velocities through atrioventricular and semilunar valves and the umbilical artery were measured. Measurements were converted to z scores based on published normal data. Results Fetuses determined after birth to be HIV-infected had similar echocardiographic findings as fetuses later determined to be HIV-uninfected except for slightly smaller left ventricular diastolic dimensions (P = .01). The femur length (P = .03) was also smaller in the fetuses postnatally identified as HIV-infected. Differences in cardiovascular dimensions and Doppler velocities were identified between fetuses of HIV-infected women and previously published normal fetal data. The reason for the differences may be a result of maternal HIV infection, maternal risk factors, or selection bias in the external control data. Conclusions Vertically transmitted HIV infection may be associated with reduced left ventricular size but not with altered cardiac function in utero. Fetuses of HIV-infected mothers may have abnormal cardiovascular structure and function and increased placental vascular resistance, regardless of whether the fetuses are subsequently found to be infected with HIV. (Am Heart J 2000;140:575-84.)

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.1372 Lipodystrophy
Web Of Science research areas: Cardiac & Cardiovascular Systems
ESI research areas: Clinical Medicine

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Title: Cardiac structure and function in fetuses of mothers infected with HIV: The prospective P2C2HIV multicenter study
Creators: Lisa K Hornberger - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Steven E Lipshultz - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Kirk A Easley - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Steven D Colan - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Marcy Schwartz - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Samuel Kaplan - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Thomas J Starc - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Nancy A Ayres - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Wyman W Lai - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Douglas S Moodie - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Carol Kasten-Sportes - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
Stephen P Sanders - From the aDepartment of Cardiology, Children’s Hospital, Department of Pediatrics, Harvard Medical School, and bDepartment of Pediatrics, Boston Medical Center and Boston University School of Medicine.cDepartment of Biostatistics and Epidemiology and dDepartment of Pediatrics, Division of Pediatric Cardiology, Cleveland Clinic Foundation.eDepartment of Pediatrics, Division of Pediatric Cardiology, University of California, Los Angeles Medical Center and School of Medicine.fDepartment of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University School of Medicine.gDepartment of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston.hDepartment of Pediatrics, Division of Pediatric Cardiology, Mt Sinai School of Medicine, New York; and the iNational Heart, Lung, and Blood Institute, Bethesda
for the P
Publication Details: The American heart journal, Vol.140(4), pp.575-584
Publisher: Mosby, Inc
Academic Unit: UMMG Department of Pediatrics
Language: English
Resource Type: Journal article
PMID: 11011330
PMCID: PMC4309555
Record Identifier: 991031615119202976