Cell Migration and Chimerism After Whole-organ Transplantation: The Basis of Graft Acceptance

Thomas E Starzl; Anthony J Demetris; Massimo Trucco; Noriko Murase; Camillo Ricordi; Suzanne Ildstad; Hector Ramos; Satoru Todo; Andreas Tzakis; John J Fung; Michael Nalesnik; Adriana Zeevi; William A Rudert; Mirjana Kocova

doi:10.1002/hep.1840170629

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Cell Migration and Chimerism After Whole-organ Transplantation: The Basis of Graft Acceptance

Journal article

Peer reviewed

Cell Migration and Chimerism After Whole-organ Transplantation: The Basis of Graft Acceptance

Thomas E Starzl, Anthony J Demetris, Massimo Trucco, Noriko Murase, Camillo Ricordi, Suzanne Ildstad, Hector Ramos, Satoru Todo, Andreas Tzakis, John J Fung, …

Hepatology (Baltimore, Md.), Vol.17(6), pp.1127-1152

1993-06

DOI: https://doi.org/10.1002/hep.1840170629

PMID: 8514264

Abstract

Improvements in the prevention or control of rejection of the kidney and liver have been largely interchangeable ( 1 , 2 ) and then applicable, with very little modification, to thoracic and other organs. However, the mechanism by which anti rejection treatment permits any of these grafts to be “accepted” has been an immunological enigma ( 3 , 4 ). We have proposed recently that the exchange of migratory leukocytes between the transplant and the recipient with consequent long-term cellular chimerism in both is the basis for acceptance of all whole-organ allografts and xenografts ( 5 ). Although such chimerism was demonstrated only a few months ago, the observations have increased our insight into transplantation immunology and have encouraged the development of alternative therapeutic strategies ( 6 ).

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Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.127 T Cell Receptor
Web Of Science research areas: Gastroenterology & Hepatology
ESI research areas: Clinical Medicine

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Details

Title: Cell Migration and Chimerism After Whole-organ Transplantation: The Basis of Graft Acceptance
Creators: Thomas E Starzl - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Anthony J Demetris - Department of Pathology, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Massimo Trucco - Department of Pathology, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Noriko Murase - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Camillo Ricordi - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Suzanne Ildstad - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Hector Ramos - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Satoru Todo - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Andreas Tzakis - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
John J Fung - Pittsburgh Transplant Institute and the Department of Surgery, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Michael Nalesnik - Department of Pathology, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Adriana Zeevi - Department of Pathology, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
William A Rudert - Department of Pediatrics, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Mirjana Kocova - Department of Pediatrics, University of Pittsburgh, Health Science Center, Pittsburgh, Pennsylvania 15213
Publication Details: Hepatology (Baltimore, Md.), Vol.17(6), pp.1127-1152
Academic Unit: Leadership Department; Miller School of Medicine; Diabetes Research Institute (DRI)
Language: English
Resource Type: Journal article
PMID: 8514264
Record Identifier: 991031561559502976