Abstract
PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.
- Title
- Cis interactions make immune checkpoint blockade more trans -parent
- Creators
- Natasha Khatwani - Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USAAsha B Pillai - Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA
- Publication Details
- Science immunology, Vol.5(43), p.eaba7107
- Academic Unit
- Miller School of Medicine; UMMG Department of Pediatrics; UMMG Dept of Pediatrics - Hematology/Oncology/Stem Cell Transp
- Language
- English
- Resource Type
- Journal article
- PMID
- 31901070
- Record Identifier
- 991031600264502976