Clinical Outcomes and Bacterial Characteristics of Carbapenem-Resistant Acinetobacter baumannii Among Patients from Different Global Regions

Minggui Wang; Lizhao Ge; Liang Chen; Lauren Komarow; Blake Hanson; Jinnethe Reyes; Eric Cober; Thamer Alenazi; Zhiyong Zong; Qing Xie; Zhengyin Liu; Lanjuan Li; Yunsong Yu; Hainv Gao; Souha S Kanj; Jairo Figueroa; Erica Herc; Ezequiel Cordova; Gregory Weston; Paul Ananth Tambyah; Julia Garcia-Diaz; Keith S Kaye; Sorabh Dhar; Jose M Munita; Robert A Salata; Samuel Vilchez; Martin E Stryjewski; Maria Virginia Villegas Botero; Alina Iovleva; Scott Evans; Keri Baum; Carol Hill; Barry N Kreiswirth; Robin Patel; David L Paterson; Cesar A Arias; Robert A Bonomo; Henry F Chambers; Vance G Fowler; Michael J Satlin; David van Duin; Yohei Doi; Fujie Zhang; Judith J Lok; Martin Stryjewski; Valentina Di Castelnuovo; Jose Millan Oñate Gutierrez; Susan Richter; Deverick J Anderson; Beth Evans; Heather R Cross; Rebekka Arias; Karen Ordoñez; Jesse T Jacob; Linghua Li; Claudia Manca; Samit Desai; Maria Rioseco; Marisa L Sanchez; Sandra Valderrama; An Q Dinh; Diane Panesso; Kirsten Rydell; Truc T Tran; Fupin Hu; Jiachun Su; Jianping Jiang; Xiaogang Xu; Yang Yang; Maria Spencer; Steven H Marshall; Susan D Rudin; Charles Huskins; Kerry Greenwood-Quaintance; Suzannah Schmidt-Malan; Sara Revolinski; Glenn Wortmann; Robert C Kalayjian; Belinda Ostrowsky; Gopi Patel; Daniel Eiras; Angela Kim; Soraya Salcedo; John J Farrell; Andrew Henderson; Mary Waters; Bettina C Fries; Brandon Eilertson; Kalisvar Marimuthu; Oon Tek Ng; Partha Pratim De; Kean Lee Chew; Nares Smitasin; Jason C Gallagher; Anton Peleg; Marcel Leroi; Yonghong Xiao; Todd McCarty; Omai B Garner; Lilian M Abbo; Ebbing Lautenbach; Jennifer H Han; Darren Wong; Lorena Diaz; Federico Perez; Ritu Banerjee; Lars F Westblade; Multi-Drug Resistant Organism Network Investigators

doi:10.1093/cid/ciad556

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Clinical Outcomes and Bacterial Characteristics of Carbapenem-Resistant Acinetobacter baumannii Among Patients from Different Global Regions

Journal article

Peer reviewed

Clinical Outcomes and Bacterial Characteristics of Carbapenem-Resistant Acinetobacter baumannii Among Patients from Different Global Regions

Minggui Wang, Lizhao Ge, Liang Chen, Lauren Komarow, Blake Hanson, Jinnethe Reyes, Eric Cober, Thamer Alenazi, Zhiyong Zong, Qing Xie, …

Clinical infectious diseases

2023-09-20

DOI: https://doi.org/10.1093/cid/ciad556

Appears in Miller School of Medicine - Latest Publications

Abstract

Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAb) is one of the most problematic antimicrobial-resistant bacteria. We sought to elucidate the international epidemiology and clinical impact of CRAb. Methods In a prospective observational cohort study, 842 hospitalized patients with a clinical CRAb culture were enrolled at 46 hospitals in five global regions between 2017 and 2019. The primary outcome was all-cause mortality at 30 days from the index culture. The strains underwent whole-genome analysis. Results Of 842 cases, 536 (64%) represented infection. By 30 days, 128 (24%) of the infected patients died, ranging from 1 (6%) of 18 in Australia-Singapore to 54 (25%) of 216 in the United States and 24 (49%) of 49 in South-Central America, whereas 42 (14%) of non-infected patients died. Bacteremia was associated with a higher risk of death compared with other types of infection (40 [42%] of 96 vs. 88 [20%] of 440). In a multivariable logistic regression analysis, bloodstream infection and higher age-adjusted Charlson comorbidity index were independently associated with 30-day mortality. Clonal group 2 (CG2) strains predominated except in South-Central America, ranging from 216 (59%) of 369 in the United States to 282 (97%) of 291 in China. Acquired carbapenemase genes were carried by 769 (91%) of the 842 isolates. CG2 strains were significantly associated with higher levels of meropenem resistance, yet non-CG2 cases were over-represented among the deaths compared with CG2 cases. Conclusions CRAb infection types and clinical outcomes differed significantly across regions. While CG2 strains remained predominant, non-CG2 strains were associated with higher mortality. ClinicalTrials.gov #NCT03646227

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.146 Antibiotic Resistance
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology

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Title: Clinical Outcomes and Bacterial Characteristics of Carbapenem-Resistant Acinetobacter baumannii Among Patients from Different Global Regions
Creators: Minggui Wang - Huashan Hospital
Lizhao Ge - George Washington University
Liang Chen - Center for Discovery
Lauren Komarow - George Washington University
Blake Hanson - The University of Texas Health Science Center at Houston
Jinnethe Reyes - Universidad El Bosque
Eric Cober - Cleveland Clinic
Thamer Alenazi - King Abdulaziz Medical City
Zhiyong Zong - West China Hospital of Sichuan University
Qing Xie - Ruijin Hospital
Zhengyin Liu - Peking Union Medical College Hospital
Lanjuan Li - First Affiliated Hospital Zhejiang University
Yunsong Yu - Sir Run Run Shaw Hospital
Hainv Gao
Souha S Kanj - American University of Beirut Medical Center
Jairo Figueroa - Hospital Universitario de Santander
Erica Herc - Henry Ford Hospital
Ezequiel Cordova - Argerich Hospital
Gregory Weston - Albert Einstein College of Medicine
Paul Ananth Tambyah
Julia Garcia-Diaz
Keith S Kaye - University of Michigan–Ann Arbor
Sorabh Dhar - Wayne State University
Jose M Munita - Universidad del Desarrollo
Robert A Salata - Case Western Reserve University
Samuel Vilchez - National Autonomous University of Nicaragua
Martin E Stryjewski - Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
Maria Virginia Villegas Botero
Alina Iovleva - University of Pittsburgh
Scott Evans - National Health and Family Planning Commission
Keri Baum
Carol Hill - Clinical Research Institute
Barry N Kreiswirth - Center for Discovery
Robin Patel - Mayo Clinic in Arizona
David L Paterson - Royal Brisbane and Women's Hospital
Cesar A Arias - Houston Methodist
Robert A Bonomo - Louis Stokes Cleveland VA Medical Center
Henry F Chambers - University of California, San Francisco
Vance G Fowler - Clinical Research Institute
Michael J Satlin - Cornell University
David van Duin - University of North Carolina at Chapel Hill
Yohei Doi - University of Pittsburgh
Souha S Kanj - American University of Beirut Medical Center
Fujie Zhang
Judith J Lok
Robert A Salata - Case Western Reserve University
Martin Stryjewski - Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
Valentina Di Castelnuovo
Jose Millan Oñate Gutierrez
Eric Cober - Cleveland Clinic
Susan Richter
Deverick J Anderson
Beth Evans
Carol Hill - Clinical Research Institute
Heather R Cross
Keri Baum
Rebekka Arias
Vance G Fowler - Clinical Research Institute
Karen Ordoñez
Jesse T Jacob
Linghua Li
Barry N Kreiswirth - Center for Discovery
Claudia Manca
Liang Chen - Center for Discovery
Samit Desai
Erica Herc - Henry Ford Hospital
Ezequiel Cordova - Argerich Hospital
Maria Rioseco
Samuel Vilchez - National Autonomous University of Nicaragua
Marisa L Sanchez
Sandra Valderrama
Jairo Figueroa - Hospital Universitario de Santander
Cesar A Arias - Houston Methodist
An Q Dinh
Diane Panesso
Kirsten Rydell
Truc T Tran
Fupin Hu
Jiachun Su
Jianping Jiang
Minggui Wang - Huashan Hospital
Xiaogang Xu
Yang Yang
Jose M Munita - Universidad del Desarrollo
Maria Spencer
Thamer Alenazi - King Abdulaziz Medical City
Robert A Bonomo - Louis Stokes Cleveland VA Medical Center
Steven H Marshall
Susan D Rudin
Charles Huskins
Kerry Greenwood-Quaintance
Robin Patel - Mayo Clinic in Arizona
Suzannah Schmidt-Malan
Sara Revolinski
Glenn Wortmann
Robert C Kalayjian
Gregory Weston - Albert Einstein College of Medicine
Belinda Ostrowsky
Gopi Patel
Daniel Eiras
Angela Kim
Julia Garcia-Diaz
Soraya Salcedo
John J Farrell
Zhengyin Liu - Peking Union Medical College Hospital
Andrew Henderson
David L Paterson - Royal Brisbane and Women's Hospital
Qing Xie - Ruijin Hospital
Keith S Kaye - University of Michigan–Ann Arbor
Hainv Gao
Yunsong Yu - Sir Run Run Shaw Hospital
Mary Waters
Bettina C Fries
Brandon Eilertson
Kalisvar Marimuthu
Oon Tek Ng
Partha Pratim De
Kean Lee Chew
Nares Smitasin
Paul Ananth Tambyah - National University of Singapore
Jason C Gallagher
Anton Peleg
Marcel Leroi
Lanjuan Li - First Affiliated Hospital Zhejiang University
Yonghong Xiao
Lauren Komarow - George Washington University
Lizhao Ge - George Washington University
Scott Evans - National Health and Family Planning Commission
Todd McCarty
Henry F Chambers - University of California, San Francisco
Omai B Garner
Lilian M Abbo
David van Duin - University of North Carolina at Chapel Hill
Ebbing Lautenbach
Jennifer H Han
Yohei Doi - University of Pittsburgh
Darren Wong
Blake Hanson - The University of Texas Health Science Center at Houston
Jinnethe Reyes - Universidad El Bosque
Maria Virginia Villegas Botero
Lorena Diaz
Federico Perez
Ritu Banerjee
Sorabh Dhar - Wayne State University
Michael J Satlin - Cornell University
Lars F Westblade
Zhiyong Zong - West China Hospital of Sichuan University
Multi-Drug Resistant Organism Network Investigators
Publication Details: Clinical infectious diseases
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Infectious Diseases
Language: English
Resource Type: Journal article
Record Identifier: 991031935618502976