Abstract
Estimating biomechanical properties of the
crystalline lens remains a challenge and is a barrier to evaluating novel lens softening therapies. There is a need to estimate quantitative biomechanical properties of the human anterior and mid segments of the eye
for conditions such as presbyopia.
We aim to develop a multimodal elastography device that enables high-performance sequential 3D imaging with both Brillouin microscopy and optical coherence elastography (OCE).
We combined Brillouin spectroscopy and OCE on a modified slit lamp platform for human measurements. The multimodal system was first characterized and then tested on both a porcine eye and a human subject.
Both OCE and Brillouin microscopy were characterized at peak operating performance for clinical imaging. Successful measurements of an
porcine lens and a human
lens are reported.
We demonstrated the first successful multimodal OCE and Brillouin microscopy measurement in a human subject. This instrument offers the potential to characterize the biomechanical status of presbyopia with age.