Commentary: sex difference differences? A reply to Constantino

Daniel S Messinger; Gregory S Young; Sara Jane Webb; Sally Ozonoff; Susan E Bryson; Alice Carter; Leslie Carver; Tony Charman; Katarzyna Chawarska; Suzanne Curtin; Karen Dobkins; Irva Hertz-Picciotto; Ted Hutman; Jana M Iverson; Rebecca Landa; Charles A Nelson; Wendy L Stone; Helen Tager-Flusberg; Lonnie Zwaigenbaum

doi:10.1186/s13229-016-0093-9.

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Commentary: sex difference differences? A reply to Constantino

Journal article

Open access

Peer reviewed

Commentary: sex difference differences? A reply to Constantino

Daniel S Messinger, Gregory S Young, Sara Jane Webb, Sally Ozonoff, Susan E Bryson, Alice Carter, Leslie Carver, Tony Charman, Katarzyna Chawarska, Suzanne Curtin, …

Molecular autism, Vol.7(1), p.31

2016

DOI: https://doi.org/10.1186/s13229-016-0093-9.

PMCID: PMC4926305

PMID: 27358719

Abstract

Female protective effect

Sex differences

Autism spectrum disorder

High-risk siblings

Messinger et al. found a 3.18 odds ratio of male to female ASD recurrence in 1241 prospectively followed high-risk (HR) siblings. Among high-risk siblings (with and without ASD), as well as among 583 low-risk controls, girls exhibited higher performance on the Mullen Scales of Early Learning, as well as lower restricted and repetitive behavior severity scores on the Autism Diagnostic Observation Schedule (ADOS) than boys. That is, female-favoring sex differences in developmental performance and autism traits were evident among low-risk and non-ASD high-risk children, as well as those with ASD. Constantino (Mol Autism) suggests that sex differences in categorical ASD outcomes in Messinger et al. should be understood as a female protective effect. We are receptive to Constantino's (Mol Autism) suggestion, and propose that quantitative sex differences in autism-related features are keys to understanding this female protective effect.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.136 Autism & Development Disorders; 1.136.283 Autism
Web Of Science research areas: Genetics & Heredity; Neurosciences
ESI research areas: Molecular Biology & Genetics

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Title: Commentary: sex difference differences? A reply to Constantino
Creators: Daniel S Messinger - University of Miami, Coral Gables, USA
Gregory S Young - University of California, Davis, Davis, USA
Sara Jane Webb - Seattle Children's Research Institute, Seattle, USA ; University of Washington, Seattle, USA
Sally Ozonoff - University of California, Davis, Davis, USA
Susan E Bryson - Izaak Walton Killam Health Centre, Halifax, Canada ; Dalhousie University, Halifax, Canada
Alice Carter - University of Massachusetts, Boston, Boston, USA
Leslie Carver - University of California, San Diego, La Jolla, USA
Tony Charman - King's College London, London, UK
Katarzyna Chawarska - Yale University School of Medicine, New Haven, USA
Suzanne Curtin - University of Calgary, Calgary, Canada
Karen Dobkins - University of California, San Diego, La Jolla, USA
Irva Hertz-Picciotto - University of California, Davis, Davis, USA
Ted Hutman - University of California, Los Angeles, Los Angeles, USA
Jana M Iverson - University of Pittsburgh, Pittsburgh, USA
Rebecca Landa - Kennedy Krieger Institute, Baltimore, USA ; John Hopkins School of Medicine, Baltimore, USA
Charles A Nelson - Harvard Medical School, Boston, USA ; Harvard Graduate School of Education, Cambridge, USA ; Boston Children's Hospital, Boston, USA
Wendy L Stone - University of Washington, Seattle, USA
Helen Tager-Flusberg - Boston University, Boston, USA
Lonnie Zwaigenbaum - University of Alberta, Edmonton, Canada
Publication Details: Molecular autism, Vol.7(1), p.31
Publisher: England
Grant note: P50 HD055782 / NICHD NIH HHS R01DC010290 / NIDCD NIH HHS Medical Research Council U54 HD079123 / NICHD NIH HHS R21DC008637 / NIDCD NIH HHS R01HD057284 / NICHD NIH HHS U54 MH068172 / NIMH NIH HHS Canadian Institutes of Health Research R21 DC008637 / NIDCD NIH HHS P50 HD055784 / NICHD NIH HHS P50HD055782 / NICHD NIH HHS K01 MH096961 / NIMH NIH HHS U54 HD090255 / NICHD NIH HHS R01 MH087554 / NIMH NIH HHS U54 HD083091 / NICHD NIH HHS R01 MH059630 / NIMH NIH HHS R01 HD054979 / NICHD NIH HHS R01 HD064820 / NICHD NIH HHS R01 DC010290 / NIDCD NIH HHS R01 MH068398 / NIMH NIH HHS P01HD003008 / NICHD NIH HHS R01MH068398 / NIMH NIH HHS P50 HD55784 / NICHD NIH HHS R01GM105004 / NIGMS NIH HHS R01 HD057284 / NICHD NIH HHS R01MH087554 / NIMH NIH HHS R01HD054979 / NICHD NIH HHS R01 GM105004 / NIGMS NIH HHS K01MH096961 / NIMH NIH HHS R01HD064820 / NICHD NIH HHS P01 HD003008 / NICHD NIH HHS R01MH059630 / NIMH NIH HHS
Academic Unit: College of A&S; A&S - Psychology
Language: English
Resource Type: Journal article
PMID: 27358719
PMCID: PMC4926305
Record Identifier: 991031560622002976