Abstract
We compared original rosehip powder consisting of whole rosehips including seeds, with two different doses of a novel enhanced rosehip powder of rosehips without their seeds, for patients with knee osteoarthritis (OA).
A total of 150 patients with symptomatic knee OA were randomly assigned to original powder (six capsules/day), enhanced powder (six capsules/day) or enhanced powder (three capsules/day). The primary outcome was change from baseline in the Knee Injury and Osteoarthritis Outcome Score (KOOS) item, 'pain during walking on flat surface , assessed after 12 weeks. Statistical analyses were based on the intention-to-treat population.
During the trial period the change in the primary outcome was comparable across groups. Changes in the KOOS symptoms supported a potential superiority of enhanced powder versus original powder, with a difference of 5.97 KOOS points (95% CI: 0.92-11.02; p = 0.02).
Enhanced rosehip powder is at least as good, even taken as three capsules/day, as the original rosehip product for patients with symptomatic OA.