Complement Activation and Corticosteroid Therapy in the Development of the Adult Respiratory Distress Syndrome

Roland M.H Schein; Robert Bergman; Eileen H Marcial; Duane Schultz; Robert C Duncan; Patricia I Arnold; Charles L Sprung

doi:10.1378/chest.91.6.850

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Complement Activation and Corticosteroid Therapy in the Development of the Adult Respiratory Distress Syndrome

Journal article

Peer reviewed

Complement Activation and Corticosteroid Therapy in the Development of the Adult Respiratory Distress Syndrome

Roland M.H Schein, Robert Bergman, Eileen H Marcial, Duane Schultz, Robert C Duncan, Patricia I Arnold and Charles L Sprung

Chest, Vol.91(6), pp.850-854

1987-06

DOI: https://doi.org/10.1378/chest.91.6.850

PMID: 3556054

Abstract

Fifty-nine patients in septic shock were observed for the development of the adult respiratory distress syndrome (ARDS) prior to and after receiving either 30 mg/kg methylprednisolone sodium succinate, 6 mg/kg dexamethasone sodium phosphate or no steroid. Serum levels of C3, C4 and Factor B allowed classification of 42 patients by activation of complement pathways. Despite a trend toward patients with severe septic shock who activate the alternative pathway being protected from the development of ARDS, complement pathway determination did not allow prediction of the development of ARDS and steroid pretreatment did not influence complement levels or prevent ARDS.

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Citation topics: 1 Clinical & Life Sciences; 1.154 Assisted Ventilation; 1.154.277 Mechanical Ventilation
Web Of Science research areas: Critical Care Medicine; Respiratory System
ESI research areas: Clinical Medicine

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Details

Title: Complement Activation and Corticosteroid Therapy in the Development of the Adult Respiratory Distress Syndrome
Creators: Roland M.H Schein - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Robert Bergman - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Eileen H Marcial - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Duane Schultz - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Robert C Duncan - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Patricia I Arnold - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Charles L Sprung - From the Section of Critical Care, Divisions of General Medicine and Immunology, Departments of Medicine and Biostatistics, Veterans Administration Medical Center, University of Miami School of Medicine, Miami
Publication Details: Chest, Vol.91(6), pp.850-854
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; UMMG Department of Public Health Sciences Research; UMMG Dept of Medicine - Pulmonary, Critical Care & Sleep Medicine
Language: English
Resource Type: Journal article
PMID: 3556054
Record Identifier: 991031614985502976