Complete genome sequence of an M1 strain of Streptococcus pyogenes

Joseph J Ferretti; William M McShan; Dragana Ajdic; Dragutin J Savic; Gorana Savic; Kevin Lyon; Charles Primeaux; Steven Sezate; Alexander N Suvorov; Steve Kenton; Hong Shing Lai; Shao Ping Lin; Yudong Qian; Hong Gui Jia; Fares Z Najar; Qun Ren; Hua Zhu; Lin Song; Jim White; Xiling Yuan; Sandra W Clifton; Bruce A Roe; Robert McLaughlin

doi:10.1073/pnas.071559398

Back

Complete genome sequence of an M1 strain of Streptococcus pyogenes

Journal article

Open access

Complete genome sequence of an M1 strain of Streptococcus pyogenes

Joseph J Ferretti, William M McShan, Dragana Ajdic, Dragutin J Savic, Gorana Savic, Kevin Lyon, Charles Primeaux, Steven Sezate, Alexander N Suvorov, Steve Kenton, …

Proceedings of the National Academy of Sciences - PNAS, Vol.98(8), pp.4658-4663

2001-04-10

DOI: https://doi.org/10.1073/pnas.071559398

PMCID: PMC31890

PMID: 11296296

Abstract

Biological Sciences

The 1,852,442-bp sequence of an M1 strain of Streptococcus pyogenes , a Gram-positive pathogen, has been determined and contains 1,752 predicted protein-encoding genes. Approximately one-third of these genes have no identifiable function, with the remainder falling into previously characterized categories of known microbial function. Consistent with the observation that S. pyogenes is responsible for a wider variety of human disease than any other bacterial species, more than 40 putative virulence-associated genes have been identified. Additional genes have been identified that encode proteins likely associated with microbial “molecular mimicry” of host characteristics and involved in rheumatic fever or acute glomerulonephritis. The complete or partial sequence of four different bacteriophage genomes is also present, with each containing genes for one or more previously undiscovered superantigen-like proteins. These prophage-associated genes encode at least six potential virulence factors, emphasizing the importance of bacteriophages in horizontal gene transfer and a possible mechanism for generating new strains with increased pathogenic potential.

Files and links (1)

url

https://doi.org/10.1073/pnas.071559398View

Published (Version of record) Open

Metrics

35 Record Views

742 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.1051 Necrotizing Fasciitis
Web Of Science research areas: Biochemistry & Molecular Biology
ESI research areas: Immunology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Complete genome sequence of an M1 strain of Streptococcus pyogenes
Creators: Joseph J Ferretti - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
William M McShan - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Dragana Ajdic - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Dragutin J Savic - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Gorana Savic - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Kevin Lyon - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Charles Primeaux - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Steven Sezate - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Alexander N Suvorov - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Steve Kenton - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Hong Shing Lai - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Shao Ping Lin - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Yudong Qian - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Hong Gui Jia - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Fares Z Najar - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Qun Ren - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Hua Zhu - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Lin Song - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Jim White - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Xiling Yuan - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Sandra W Clifton - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Bruce A Roe - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Robert McLaughlin - Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190; and
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.98(8), pp.4658-4663
Publisher: National Academy of Sciences
Academic Unit: Miller School of Medicine; UMMG Dept of Dermatology & Cutaneous Surgery
Language: English
Resource Type: Journal article
PMID: 11296296
PMCID: PMC31890
Record Identifier: 991031613138202976