Conjugated Quantum Dots Inhibit the Amyloidβ(1–42) Fibrillation Process

Garima Thakur; Miodrag Micic; Yuehai Yang; Wenzhi Li; Dania Movia; Silvia Giordani; Hongzhou Zhang; Roger M Leblanc

doi:10.4061/2011/502386

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Conjugated Quantum Dots Inhibit the Amyloidβ(1–42) Fibrillation Process

Journal article

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Conjugated Quantum Dots Inhibit the Amyloidβ(1–42) Fibrillation Process

Garima Thakur, Miodrag Micic, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhang and Roger M Leblanc

International journal of alzheimer's disease, Vol.2011, pp.1-15

2011

DOI: https://doi.org/10.4061/2011/502386

PMCID: PMC3056432

PMID: 21423556

Abstract

Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloidβ(1–42) (Aβ(1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.

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Title: Conjugated Quantum Dots Inhibit the Amyloidβ(1–42) Fibrillation Process
Creators: Garima Thakur - 1301 Memorial Drive, Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA
Miodrag Micic - MP Biomedicals LLC, 3 Hutton Center, Santa Ana, CA 92707, USA, Department of Mechanical and Aerospace Engineering, University of California, 4200 Engineering Gateway Building, Irvine, CA 92697-3975, USA
Yuehai Yang - Department of Physics, Florida International University, Miami, FL 33199, USA
Wenzhi Li - Department of Physics, Florida International University, Miami, FL 33199, USA
Dania Movia - School of Chemistry, College Green, Trinity College Dublin, Dublin 2, Ireland, Centre of Research on Advanced Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2, Ireland
Silvia Giordani - School of Chemistry, College Green, Trinity College Dublin, Dublin 2, Ireland, Centre of Research on Advanced Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2, Ireland
Hongzhou Zhang - Centre of Research on Advanced Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2, Ireland, School of Physics, College Green, Trinity College Dublin, Dublin 2, Ireland
Roger M Leblanc - 1301 Memorial Drive, Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA
Publication Details: International journal of alzheimer's disease, Vol.2011, pp.1-15
Academic Unit: Leadership Department; College of A&S; A&S - Chemistry
Language: English
Resource Type: Journal article
PMID: 21423556
PMCID: PMC3056432
Record Identifier: 991031561030802976