Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M McDowell; Krishnakumar Kizhatil; Michael H Elliott; Darryl R Overby; Joseph van Batenburg-Sherwood; J Cameron Millar; Markus H Kuehn; Gulab Zode; Ted S Acott; Michael G Anderson; Sanjoy K Bhattacharya; Jacques A Bertrand; Terete Borras; Diane E Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A Faralli; Rudolf Fuchshofer; Preethi S Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W M John; Paul L Kaufman; Kate E Keller; Mary J Kelley; Ruth A Kelly; David Krizaj; Ajay Kumar; Brian C Leonard; Raquel L Lieberman; Paloma Liton; Yutao Liu; Katy C Liu; Navita N Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J McLellan; Philip Mzyk; Andrews Nartey; Louis R Pasquale; Gaurang C Patel; Padmanabhan P Pattabiraman; Donna M Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R Samples; E Griffen Samples; Najam Sharif; Joel S Schuman; Val C Sheffield; Cooper H Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B Toris; Karen Y Torrejon; Amir Vahabikashi; Janice A Vranka; Ting Wang; Colin E Willoughby; Chen Xin; Hongmin Yun; Hao F Zhang; Michael P Fautsch; Ernst R Tamm; Abbot F Clark; C Ross Ethier; W Daniel Stamer

doi:10.1167/iovs.63.2.12

Back

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Journal article

Open access

Peer reviewed

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M McDowell, Krishnakumar Kizhatil, Michael H Elliott, Darryl R Overby, Joseph van Batenburg-Sherwood, J Cameron Millar, Markus H Kuehn, Gulab Zode, Ted S Acott, Michael G Anderson, …

Investigative ophthalmology & visual science, Vol.63(2), pp.12-12

2022-02-01

DOI: https://doi.org/10.1167/iovs.63.2.12

PMID: 35129590

Appears in Miller School of Medicine - Latest Publications

Abstract

Animals

Aqueous Humor - physiology

Consensus

Disease Models, Animal

Glaucoma - metabolism

Glaucoma - physiopathology

Intraocular Pressure - physiology

Mice

Ocular Hypertension - metabolism

Ocular Hypertension - physiopathology

Tonometry, Ocular

Trabecular Meshwork - metabolism

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Files and links (1)

url

https://doi.org/10.1167/iovs.63.2.12View

Published (Version of record) Open

Metrics

9 Record Views

17 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.36 Ophthalmology; 1.36.226 Glaucoma
Web Of Science research areas: Ophthalmology
ESI research areas: Clinical Medicine

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms
Creators: Colleen M McDowell - Visual Sciences
Krishnakumar Kizhatil - Jackson Laboratory
Michael H Elliott - University of Oklahoma Health Sciences Center
Darryl R Overby - Imperial College London
Joseph van Batenburg-Sherwood - Imperial College London
J Cameron Millar - University of North Texas Health Science Center
Markus H Kuehn - Visual Sciences
Gulab Zode - University of North Texas Health Science Center
Ted S Acott - Oregon Health & Science University
Michael G Anderson - Visual Sciences
Sanjoy K Bhattacharya - University of Miami
Jacques A Bertrand - Imperial College London
Terete Borras - University of North Carolina at Chapel Hill
Diane E Bovenkamp - BrightFocus Foundation
Lin Cheng - Visual Sciences
John Danias - SUNY Downstate Medical Center
Michael Lucio De Ieso - Duke University
Yiqin Du - University of Pittsburgh
Jennifer A Faralli - University of Wisconsin–Madison
Rudolf Fuchshofer - University of Regensburg
Preethi S Ganapathy - SUNY Upstate Medical University
Haiyan Gong - Boston University
Samuel Herberg - SUNY Upstate Medical University
Humberto Hernandez - University of Houston - Victoria
Peter Humphries - Trinity College Dublin
Simon W M John - Columbia University
Paul L Kaufman - Visual Sciences
Kate E Keller - Oregon Health & Science University
Mary J Kelley - Oregon Health & Science University
Ruth A Kelly - Trinity College Dublin
David Krizaj - University of Utah
Ajay Kumar - University of Pittsburgh
Brian C Leonard - University of California, Davis
Raquel L Lieberman - Georgia Institute of Technology
Paloma Liton - Duke University
Yutao Liu - Discovery Institute
Katy C Liu - Duke Medical Center
Navita N Lopez - University of Utah
Weiming Mao - Indiana University
Timur Mavlyutov - Visual Sciences
Fiona McDonnell - Duke Medical Center
Gillian J McLellan - Visual Sciences
Philip Mzyk - Visual Sciences
Andrews Nartey - University of Houston
Louis R Pasquale - Icahn School of Medicine at Mount Sinai
Gaurang C Patel - Regeneron
Padmanabhan P Pattabiraman - Indiana University
Donna M Peters - University of Wisconsin–Madison
Vijaykrishna Raghunathan - University of Houston
Ponugoti Vasantha Rao - Duke University
Naga Rayana - Indiana University
Urmimala Raychaudhuri - University of California, Irvine
Ester Reina-Torres - Imperial College London
Ruiyi Ren - Boston University
Douglas Rhee - Case Western Reserve University
Uttio Roy Chowdhury - Mayo Clinic
John R Samples - Washington State University Spokane
E Griffen Samples - Glaucoma Foundation
Najam Sharif - Santen
Joel S Schuman - New York University
Val C Sheffield - University of Iowa
Cooper H Stevenson - University of North Texas Health Science Center
Avinash Soundararajan - Indiana University
Preeti Subramanian - BrightFocus Foundation
Chenna Kesavulu Sugali - Indiana University
Yang Sun - VA Palo Alto Health Care System
Carol B Toris - University of Nebraska Medical Center
Karen Y Torrejon - Glauconix
Amir Vahabikashi - Northwestern University
Janice A Vranka - Oregon Health & Science University
Ting Wang - Indiana University
Colin E Willoughby - University of Ulster
Chen Xin - Beijing Tongren Hospital
Hongmin Yun - University of Pittsburgh
Hao F Zhang - Northwestern University
Michael P Fautsch - Northwestern University
Ernst R Tamm - University of Regensburg
Abbot F Clark - University of North Texas Health Science Center
C Ross Ethier - The Wallace H. Coulter Department of Biomedical Engineering
W Daniel Stamer - Duke University
Publication Details: Investigative ophthalmology & visual science, Vol.63(2), pp.12-12
Grant note: P30 EY010572 / NEI NIH HHS R01 EY031817 / NEI NIH HHS R01 EY026885 / NEI NIH HHS P30 EY014800 / NEI NIH HHS R01 EY027920 / NEI NIH HHS R01 EY019643 / NEI NIH HHS R21 EY033073 / NEI NIH HHS F31 EY031973 / NEI NIH HHS P30 EY031631 / NEI NIH HHS R01 EY026529 / NEI NIH HHS R21 EY028671 / NEI NIH HHS R01 EY027733 / NEI NIH HHS K99 EY032547 / NEI NIH HHS
Academic Unit: UMMG Department of Ophthalmology; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 35129590
Record Identifier: 991031714493802976