Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation

Vasilios F Diakonis; Vardhaman P Kankariya; George Kounis; Aristophanis I Pallikaris; Sonia H Yoo; Ioannis G Pallikaris; George D Kymionis

doi:10.1016/j.jcrs.2013.07.049

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$Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation$

Journal article

Peer reviewed

Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation

Vasilios F Diakonis, Vardhaman P Kankariya, George Kounis, Aristophanis I Pallikaris, Sonia H Yoo, Ioannis G Pallikaris and George D Kymionis

Journal of cataract and refractive surgery, Vol.40(2), pp.224-231

2014-02

DOI: https://doi.org/10.1016/j.jcrs.2013.07.049

PMID: 24373376

Abstract

Prospective Studies

Follow-Up Studies

Cell Count

Humans

Male

Endothelium, Corneal - pathology

Lasers, Excimer - therapeutic use

Young Adult

Adult

Female

Cornea - pathology

Myopia - surgery

Refraction, Ocular - physiology

Visual Acuity - physiology

Corneal Keratocytes - pathology

Myopia - pathology

Treatment Outcome

Combined Modality Therapy

Alkylating Agents - administration & dosage

Microscopy, Confocal

Photorefractive Keratectomy

Ophthalmic Nerve - pathology

Cornea - innervation

Keratomileusis, Laser In Situ

Mitomycin - administration & dosage

To compare the visual and refractive outcomes and the corneal structural changes in myopic patients after surface refractive treatments (ie, photorefractive keratectomy [PRK] with adjuvant mitomycin-C [MMC] and epithelial laser in situ keratomileusis [epi-LASIK]). University of Crete, Heraklion, Crete, Greece. Prospective comparative case series. One eye of consecutive myopic patients was randomly assigned to PRK-MMC, and the fellow eye was treated with epi-LASIK. Visual and refractive outcomes and corneal confocal microscopy findings were evaluated. All patients were examined preoperatively and 1, 3, 6, 12, and 24 months postoperatively. Twenty-six eyes (13 patients) were included. The mean follow-up was 2.47 years ± 0.35 (SD) (range 1.64 to 2.93 years). In the PRK-MMC group, the mean preoperative spherical equivalent refraction was -3.84 ± 1.59 diopters (D) (range -1.5 to -8.7 D) and -0.21 ± 0.44 D (range -0.5 to 1.0 D) at the last follow-up and in the epi-LASIK group, -3.91 ± 1.48 D (range -1.5 to -8.5 D) and -0.18 ± 0.36 (range +0.5 to -0.5 D), respectively. Qualitative analysis of the subepithelial nerve plexus, haze development, and keratocyte distribution were similar in the 2 groups. There was no statistically significant difference in endothelial cell density between the groups throughout the follow-up (P>.05). Epithelial LASIK and PRK-MMC gave similar visual, refractive, and corneal structural outcomes in patients with myopia for up to 2 years postoperatively. No author has a financial or proprietary interest in any material or method mentioned.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.36 Ophthalmology; 1.36.141 Keratoconus
Web Of Science research areas: Ophthalmology; Surgery
ESI research areas: Clinical Medicine

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Details

Title: Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation
Creators: Vasilios F Diakonis - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA. Electronic address: diakonis@gmail.com
Vardhaman P Kankariya - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA
George Kounis - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA
Aristophanis I Pallikaris - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA
Sonia H Yoo - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA
Ioannis G Pallikaris - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA
George D Kymionis - From the Institute of Vision and Optics (Diakonis, Kankariya, Kounis, A.I. Pallikaris, I.G. Pallikaris, Kymionis), Department of Medicine, University of Crete, Heraklion, Greece; the Bascom Palmer Eye Institute (Diakonis, Kankariya, Yoo, Kymionis), Miller School of Medicine, University of Miami, Miami, Florida, USA
Publication Details: Journal of cataract and refractive surgery, Vol.40(2), pp.224-231
Publisher: United States
Academic Unit: Miller School of Medicine; UMMG Department of Ophthalmology
Language: English
Resource Type: Journal article
PMID: 24373376
Record Identifier: 991031559957102976