Convergent genetic and expression data implicate immunity in Alzheimer's disease

Lesley Jones; Jean-Charles Lambert; Li-San Wang; Seung-Hoan Choi; Denise Harold; Alexey Vedernikov; Valentina Escott-Price; Timothy Stone; Alexander Richards; Céline Bellenguez; Carla A Ibrahim-Verbaas; Adam C Naj; Rebecca Sims; Amy Gerrish; Gyungah Jun; Anita L DeStefano; Joshua C Bis; Gary W Beecham; Benjamin Grenier-Boley; Giancarlo Russo; Tricia A Thornton-Wells; Nicola Jones; Albert V Smith; Vincent Chouraki; Charlene Thomas; M. Arfan Ikram; Diana Zelenika; Badri N Vardarajan; Yoichiro Kamatani; Chiao-Feng Lin; Helena Schmidt; Brian W Kunkle; Melanie L Dunstan; Agustin Ruiz; Marie-Thérèse Bihoreau; Christiane Reitz; Florence Pasquier; Paul Hollingworth; Olivier Hanon; Annette L Fitzpatrick; Joseph D Buxbaum; Dominique Campion; Paul K Crane; Tim Becker; Vilmundur Gudnason; Carlos Cruchaga; David Craig; Najaf Amin; Claudine Berr; Oscar L Lopez; Philip L De Jager; Vincent Deramecourt; Janet A Johnston; Denis Evans; Simon Lovestone; Luc Letteneur; Johanes Kornhuber; Lluís Tárraga; David C Rubinsztein; Gudny Eiriksdottir; Kristel Sleegers; Alison M Goate; Nathalie Fiévet; Matthew J Huentelman; Michael Gill; Valur Emilsson; Kristelle Brown; M. Ilyas Kamboh; Lina Keller; Pascale Barberger-Gateau; Bernadette McGuinness; Eric B Larson; Amanda J Myers; Carole Dufouil; Stephen Todd; David Wallon; Seth Love; Pat Kehoe; Ekaterina Rogaeva; John Gallacher; Peter St George-Hyslop; Jordi Clarimon; Alberti Lleò; Anthony Bayer; Debby W Tsuang; Lei Yu; Magda Tsolaki; Paola Bossù; Gianfranco Spalletta; Petra Proitsi; John Collinge; Sandro Sorbi; Florentino Sanchez Garcia; Nick Fox; John Hardy; Maria Candida Deniz Naranjo; Cristina Razquin; Paola Bosco; Robert Clarke; Carol Brayne; Daniela Galimberti; Michelangelo Mancuso; Susanne Moebus; Patrizia Mecocci; Maria del Zompo; Wolfgang Maier; Harald Hampel; Alberto Pilotto; Maria Bullido; Francesco Panza; Paolo Caffarra; Benedetta Nacmias; John R Gilbert; Manuel Mayhaus; Frank Jessen; Martin Dichgans; Lars Lannfelt; Hakon Hakonarson; Sabrina Pichler; Minerva M Carrasquillo; Martin Ingelsson; Duane Beekly; Victoria Alavarez; Fanggeng Zou; Otto Valladares; Steven G Younkin; Eliecer Coto; Kara L Hamilton-Nelson; Ignacio Mateo; Michael J Owen; Kelley M Faber; Palmi V Jonsson; Onofre Combarros; Michael C O'Donovan; Laura B Cantwell; Hilkka Soininen; Deborah Blacker; Simon Mead; Thomas H Mosley; David A Bennett; Tamara B Harris; Laura Fratiglioni; Clive Holmes; Renee F.A.G de Bruijn; Peter Passmore; Thomas J Montine; Karolien Bettens; Jerome I Rotter; Alexis Brice; Kevin Morgan; Tatiana M Foroud; Walter A Kukull; Didier Hannequin; John F Powell; Michael A Nalls; Karen Ritchie; Kathryn L Lunetta; John S.K Kauwe; Eric Boerwinkle; Matthias Riemenschneider; Mercè Boada; Mikko Hiltunen; Eden R Martin; Pau Pastor; Reinhold Schmidt; Dan Rujescu; Jean-François Dartigues; Richard Mayeux; Christophe Tzourio; Albert Hofman; Markus M Nöthen; Caroline Graff; Bruce M Psaty; Jonathan L Haines; Mark Lathrop; Margaret A Pericak-Vance; Lenore J Launer; Lindsay A Farrer; Cornelia M van Duijn; Christine Van Broeckhoven; Alfredo Ramirez; Gerard D Schellenberg; Sudha Seshadri; Philippe Amouyel; Julie Williams; Peter A Holmans

doi:10.1016/j.jalz.2014.05.1757

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Convergent genetic and expression data implicate immunity in Alzheimer's disease

Journal article

Open access

Peer reviewed

Convergent genetic and expression data implicate immunity in Alzheimer's disease

Lesley Jones, Jean-Charles Lambert, Li-San Wang, Seung-Hoan Choi, Denise Harold, Alexey Vedernikov, Valentina Escott-Price, Timothy Stone, Alexander Richards, Céline Bellenguez, …

Alzheimer's & dementia, Vol.11(6), pp.658-671

2015-06

DOI: https://doi.org/10.1016/j.jalz.2014.05.1757

PMCID: PMC4672734

PMID: 25533204

Abstract

Pathway analysis

ALIGATOR

Endocytosis

Ubiquitination

Immune response

Neurodegeneration

Alzheimer's disease

Cholesterol metabolism

Dementia

Weighted gene co-expression network analysis

Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10−12 after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10−11), cholesterol transport (P = 2.96 × 10−9), and proteasome-ubiquitin activity (P = 1.34 × 10−6). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002–.05). The immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Disease
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior

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Title: Convergent genetic and expression data implicate immunity in Alzheimer's disease
Creators: Lesley Jones - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Jean-Charles Lambert - Inserm U744, Lille, 59000, France
Li-San Wang - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA
Seung-Hoan Choi - Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Denise Harold - Neuropsychiatric Genetics Group, Department of Psychiatry, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8
Alexey Vedernikov - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Valentina Escott-Price - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Timothy Stone - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Alexander Richards - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Céline Bellenguez - Inserm U744, Lille, 59000, France
Carla A Ibrahim-Verbaas - Department of Epidemiology, Clinical Genetics and Neurology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, The Netherlands
Adam C Naj - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Rebecca Sims - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Amy Gerrish - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Gyungah Jun - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA
Anita L DeStefano - Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Joshua C Bis - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA
Gary W Beecham - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Benjamin Grenier-Boley - Inserm U744, Lille, 59000, France
Giancarlo Russo - Functional Genomics Center, Zurich, 8038, Switzerland
Tricia A Thornton-Wells - Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212, USA
Nicola Jones - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Albert V Smith - University of Iceland, Faculty of Pharmaceutical Sciences, Reykjavik, 525-4000, Iceland
Vincent Chouraki - Inserm U744, Lille, 59000, France
Charlene Thomas - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
M. Arfan Ikram - Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, The Netherlands
Diana Zelenika - Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, 91300, France
Badri N Vardarajan - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA
Yoichiro Kamatani - Fondation Jean Dausset- CEPH, Paris, 75010, France
Chiao-Feng Lin - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA
Helena Schmidt - Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, 8010, Austria
Brian W Kunkle - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Melanie L Dunstan - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Agustin Ruiz - Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain
Marie-Thérèse Bihoreau - Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, 91300, France
Christiane Reitz - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA
Florence Pasquier - Université Lille 2, Lille, 59000, France
Paul Hollingworth - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Olivier Hanon - UMR 894 Inserm, Faculté de Médecine, Université Paris Descartes, Paris, 75014, France
Annette L Fitzpatrick - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA
Joseph D Buxbaum - Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, 10027, USA
Dominique Campion - INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, 76000, France
Paul K Crane - Department of Medicine, University of Washington, Seattle, WA, 98195, USA
Tim Becker - German Center for Neurodegenerative Diseases (DZNE, Bonn) and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany, 53113
Vilmundur Gudnason - University of Iceland, Faculty of Pharmaceutical Sciences, Reykjavik, 525-4000, Iceland
Carlos Cruchaga - Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, 98122, USA
David Craig - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, BT7 1NN, UK
Najaf Amin - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, The Netherlands
Claudine Berr - INSERM U888, Hôpital La Colombière, Montpellier, 34000, France
Oscar L Lopez - Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA
Philip L De Jager - Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02215, USA
Vincent Deramecourt - Inserm U744, Lille, 59000, France
Janet A Johnston - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, BT7 1NN, UK
Denis Evans - Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA
Simon Lovestone - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London SE5
Luc Letteneur - Inserm U897, Victor Segalen University, F-33076, Bordeaux, 33000, France
Johanes Kornhuber - Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Germany
Lluís Tárraga - Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain
David C Rubinsztein - Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 OXY, UK
Gudny Eiriksdottir - Icelandic Heart Association, Kopavogur, 525-4000, Iceland
Kristel Sleegers - Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, 2000, Belgium
Alison M Goate - Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, 98122, USA
Nathalie Fiévet - Inserm U744, Lille, 59000, France
Matthew J Huentelman - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
Michael Gill - Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Dublin 8, Ireland
Valur Emilsson - University of Iceland, Faculty of Pharmaceutical Sciences, Reykjavik, 525-4000, Iceland
Kristelle Brown - Institute of Genetics, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK
M. Ilyas Kamboh - Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15213, USA
Lina Keller - Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, 17177, Sweden
Pascale Barberger-Gateau - Inserm U897, Victor Segalen University, F-33076, Bordeaux, 33000, France
Bernadette McGuinness - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, BT7 1NN, UK
Eric B Larson - Department of Medicine, University of Washington, Seattle, WA, 98195, USA
Amanda J Myers - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, 33124, USA
Carole Dufouil - Inserm U897, Victor Segalen University, F-33076, Bordeaux, 33000, France
Stephen Todd - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, BT7 1NN, UK
David Wallon - INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, 76000, France
Seth Love - University of Bristol, Clinical Neurosciences, Level 1 Learning and Research Building BS10 5NB
Pat Kehoe - University of Bristol, Clinical Neurosciences, Level 1 Learning and Research Building BS10 5NB
Ekaterina Rogaeva - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1, Canada
John Gallacher - Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK
Peter St George-Hyslop - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5S 1A1, Canada
Jordi Clarimon - Neurology Department, IIB Sant Pau, Sant Pau Hospital, Universitat Autònoma de Barcelona, Barcelona, 08026, Spain
Alberti Lleò - Neurology Department, IIB Sant Pau, Sant Pau Hospital, Universitat Autònoma de Barcelona, Barcelona, 08026, Spain
Anthony Bayer - Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK
Debby W Tsuang - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, 98195, USA
Lei Yu - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA
Magda Tsolaki - Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621, Greece
Paola Bossù - Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, 00142, Italy
Gianfranco Spalletta - Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, 00142, Italy
Petra Proitsi - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London SE5
John Collinge - MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK
Sandro Sorbi - Department of Neurological and Psychiatric Sciences, University of Florence, Florence, 50121, Italy
Florentino Sanchez Garcia - Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, 35012, Spain
Nick Fox - Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK
John Hardy - Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, WC1N 3BG, UK
Maria Candida Deniz Naranjo - Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, 35012, Spain
Cristina Razquin - Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, 28023, Spain
Paola Bosco - IRCCS Associazione Oasi Maria SS, Troina, 94018, Italy
Robert Clarke - Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, OX1 2JD, UK
Carol Brayne - Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, CB2 1TN, UK
Daniela Galimberti - University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, 20122, Italy
Michelangelo Mancuso - Neurological Clinic, University of Pisa, 56126, Italy
Susanne Moebus - Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, 45141, Germany
Patrizia Mecocci - Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, 06100, Italy
Maria del Zompo - Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, 09123, Italy
Wolfgang Maier - Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, 53113, Germany
Harald Hampel - Université Pierre et Marie Curie, Département de Neurologie, Institut de la Mémoire et de la Maladie d’Alzheimer, Paris, France
Alberto Pilotto - Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), 71013, Italy
Maria Bullido - Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, 28046, Spain
Francesco Panza - Departement of Geriatrics, Center for Aging Brain, University of Bari, Bari, 70121, Italy
Paolo Caffarra - Department of Neuroscience-University of Parma, Parma, 43100, Italy
Benedetta Nacmias - Department of Neurological and Psychiatric Sciences, University of Florence, Florence, 50121, Italy
John R Gilbert - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Manuel Mayhaus - Dept. Of Psychiatry, University Hospital, 66424, Saarland
Frank Jessen - Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, 53113, Germany
Martin Dichgans - Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany and German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, 80336, Germany
Lars Lannfelt - Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, 75312, Sweden
Hakon Hakonarson - Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Sabrina Pichler - Dept. Of Psychiatry, University Hospital, 66424, Saarland
Minerva M Carrasquillo - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
Martin Ingelsson - Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, 75312, Sweden
Duane Beekly - National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, 98195, USA
Victoria Alavarez - Genetica molecular-Huca-Oviedo, Oviedo, 33006, Spain
Fanggeng Zou - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
Otto Valladares - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA
Steven G Younkin - Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA
Eliecer Coto - Genetica molecular-Huca-Oviedo, Oviedo, 33006, Spain
Kara L Hamilton-Nelson - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Ignacio Mateo - Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander, 39005, Spain
Michael J Owen - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Kelley M Faber - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, 46202, USA
Palmi V Jonsson - Landspitali University Hospital, Reykjavik, 543-1000, Iceland
Onofre Combarros - Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria and IFIMAV), Santander, 39005, Spain
Michael C O'Donovan - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Laura B Cantwell - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA
Hilkka Soininen - Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, 70211, Finland
Deborah Blacker - Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA
Simon Mead - MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK
Thomas H Mosley - Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA
David A Bennett - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA
Tamara B Harris - Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, 20892, USA
Laura Fratiglioni - Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, 11418, Sweden
Clive Holmes - Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, SO17 1BJ, UK
Renee F.A.G de Bruijn - Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, The Netherlands
Peter Passmore - Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, BT7 1NN, UK
Thomas J Montine - Department of Pathology, University of Washington, Seattle, WA, 98195, USA
Karolien Bettens - Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, 2000, Belgium
Jerome I Rotter - Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA
Alexis Brice - CRicm-UMRS975, Paris, France
Kevin Morgan - Institute of Genetics, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK
Tatiana M Foroud - Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, 46202, USA
Walter A Kukull - Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA
Didier Hannequin - INSERM U614, Faculté de Médecine, Centre Hospitalier du Rouvray, Rouen, 76000, France
John F Powell - King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London SE5
Michael A Nalls - Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, 20892, USA
Karen Ritchie - INSERM U888, Hôpital La Colombière, Montpellier, 34000, France
Kathryn L Lunetta - Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
John S.K Kauwe - Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 OXY, UK
Eric Boerwinkle - Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA
Matthias Riemenschneider - Department of Psychiatry, University Hospital, 66424, Saarland
Mercè Boada - Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, 8029, Spain
Mikko Hiltunen - Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, 70211, Finland
Eden R Martin - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Pau Pastor - Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research and Department of Neurology, Clínica Universidad de Navarra, University of Navarra School of Medicine, Pamplona, Spain
Reinhold Schmidt - Department of Neurology, Medical University of Graz, Graz, 8010, Austria
Dan Rujescu - Department of Psychiatry, University of Munich, Munich and University of Halle, Halle, 80336, Germany
Jean-François Dartigues - Inserm U897, Victor Segalen University, F-33076, Bordeaux, 33000, France
Richard Mayeux - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, NY, 10027, USA
Christophe Tzourio - Inserm U708, Victor Segalen University, F-33076, Bordeaux, 33000, France
Albert Hofman - Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, The Netherlands
Markus M Nöthen - Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, 53113, Germany
Caroline Graff - Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, S-14186, Stockholm
Bruce M Psaty - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA
Jonathan L Haines - Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37212, USA
Mark Lathrop - Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, 91300, France
Margaret A Pericak-Vance - The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, 33124, USA
Lenore J Launer - Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, 20892, USA
Lindsay A Farrer - Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02218, USA
Cornelia M van Duijn - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3015 CE, The Netherlands
Christine Van Broeckhoven - Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, 2000, Belgium
Alfredo Ramirez - Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, 53113, Germany
Gerard D Schellenberg - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA
Sudha Seshadri - Department of Neurology, Boston University School of Medicine, Boston, MA, 02215, USA
Philippe Amouyel - Inserm U744, Lille, 59000, France
Julie Williams - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Peter A Holmans - Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Publication Details: Alzheimer's & dementia, Vol.11(6), pp.658-671
Publisher: Elsevier Inc
Academic Unit: Miller School of Medicine; Cell Biology Research; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 25533204
PMCID: PMC4672734
Record Identifier: 991031577552502976