Sign in
Back
Cover Picture: Autocrine‐Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries (Angew. Chem. Int. Ed. 32/2016)
Journal article   Peer reviewed

Cover Picture: Autocrine‐Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries (Angew. Chem. Int. Ed. 32/2016)

Hongkai Zhang, Mingjuan Du, Jia Xie, Xiao Liu, Jingying Sun, Wei Wang, Xiu Xin, Lourival D. Possani, Kyungmoo Yea and Richard A. Lerner
Angewandte Chemie (International ed.), Vol.55(32), pp.9099-9099
2016-08-01
DOI: https://doi.org/10.1002/anie.201604909

Abstract

drug discovery ion channels peptide drugs peptides venom peptides
Animal venoms represent a rich source of pharmacologically active peptides that interact with ion channels. In their Communication on page 9306 ff., H. Zhang, R. A. Lerner et al. describe an autocrine‐based method to select functional venom peptides from their vast repertoire in nature. This method allows about 100 million different venoms to be studied in a single experiment, and its utility was demonstrated by the discovery of novel Kv1.3 channel blockers from a natural venom peptide library.

Metrics

1 Record Views

Details