Data presentation in rodent stroke studies and the predictive value of confidence intervals

Michael E Sughrue; Bartosz T Grobelny; Andrew F Ducruet; Ricardo J Komotar; J Mocco; Robert R Sciacca; E Sander Connolly

doi:10.1016/j.jocn.2009.05.008

Back

Data presentation in rodent stroke studies and the predictive value of confidence intervals

Journal article

Peer reviewed

Data presentation in rodent stroke studies and the predictive value of confidence intervals

Michael E Sughrue, Bartosz T Grobelny, Andrew F Ducruet, Ricardo J Komotar, J Mocco, Robert R Sciacca and E Sander Connolly

Journal of clinical neuroscience, Vol.17(1), pp.11-15

2010

DOI: https://doi.org/10.1016/j.jocn.2009.05.008

PMID: 19963387

Abstract

Neuroprotection

Cerebral ischemia

Focal

Data presentation

Meta-analysis

The clinical failure of neuroprotective agents stems partly from inappropriate statistical presentation of preclinical data, which causes an overestimation of effect size and underpowered clinical studies. We searched for studies utilizing neuroprotective agents in a rodent middle cerebral artery occlusion model. We identified all experimental groups demonstrating statistically significant claims of neuroprotection within these studies and calculated the mean, 95% confidence intervals (CI), and meta-analyses of effect size for each agent. The lower limits of the CI (LLCI) of effect size were less than 0.2 in 161/221 (73%) of all experimental groups, corresponding to small effects. After meta-analysis, 29/60 (48%) and 11/18 (61%) of the agents had an effect size LLCI < 0.2 for infarct volume and neurological function, respectively. This difference was statistically significant ( p < 0.05). These results suggest that the preclinical neuroprotective effect size of many of these drugs is small, although that of neurological function is smaller and is thus a more conservative and appropriate estimate of effect.

Metrics

12 Record Views

4 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.105 Strokes; 1.105.142 Stroke
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Data presentation in rodent stroke studies and the predictive value of confidence intervals
Creators: Michael E Sughrue - Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Bartosz T Grobelny - Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, Room 5-454, New York, New York 10032, USA
Andrew F Ducruet - Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, Room 5-454, New York, New York 10032, USA
Ricardo J Komotar - Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, Room 5-454, New York, New York 10032, USA
J Mocco - Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, Room 5-454, New York, New York 10032, USA
Robert R Sciacca - Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, Room 5-454, New York, New York 10032, USA
E Sander Connolly - Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, Room 5-454, New York, New York 10032, USA
Publication Details: Journal of clinical neuroscience, Vol.17(1), pp.11-15
Publisher: Elsevier Ltd
Academic Unit: Miller School of Medicine; UMMG Dept of Neurological Surgery
Language: English
Resource Type: Journal article
PMID: 19963387
Record Identifier: 991031560986302976