Abstract
To the Editor:
We have recently seen declining CD4 T-lymphocyte counts in a man with long-term, nonprogressive infection with only
nef
-deleted forms of human immunodeficiency virus type 1 (HIV-1). This patient was described in the January 26, 1995, issue of the
Journal.
1
Although he has remained asymptomatic for more than 15 years, a decline in the number of CD4 T cells first became apparent in 1997 (Table 1). Plasma viral RNA has remained undetectable. Since 1985, all efforts to culture virus, except one in 1994, have failed. Levels of viral DNA in peripheral-blood mononuclear cells have also remained low, . . .
