Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells

Lynda Elghazi; Norman Balcazar; Manuel BLANDINO-ROSANO; Corentin CRAS-MENEUR; Szabolcs Fatrai; Aaron P Gould; Maggie M Chi; Kelle H Moley; Ernesto BERNAL-MIZRACHI

doi:10.2337/db09-0851

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Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells

Journal article

Open access

Peer reviewed

Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells

Lynda Elghazi, Norman Balcazar, Manuel BLANDINO-ROSANO, Corentin CRAS-MENEUR, Szabolcs Fatrai, Aaron P Gould, Maggie M Chi, Kelle H Moley and Ernesto BERNAL-MIZRACHI

Diabetes (New York, N.Y.), Vol.59(10), pp.2390-2399

2010

DOI: https://doi.org/10.2337/db09-0851

PMCID: PMC3279560

PMID: 20622167

Abstract

Biological and medical sciences

Diabetes. Impaired glucose tolerance

Endocrine pancreas. Apud cells (diseases)

Endocrinopathies

Etiopathogenesis. Screening. Investigations. Target tissue resistance

Medical sciences

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https://doi.org/10.2337/db09-0851View

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.25 Molecular & Cell Biology - Cancer, Autophagy & Apoptosis; 1.25.803 mTOR
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Clinical Medicine

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Details

Title: Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
Creators: Lynda Elghazi - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Norman Balcazar - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Manuel BLANDINO-ROSANO - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Corentin CRAS-MENEUR - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Szabolcs Fatrai - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Aaron P Gould - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Maggie M Chi - Department of Obstetrics/Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States
Kelle H Moley - Department of Obstetrics/Gynecology, Washington University School of Medicine, St. Louis, Missouri, United States
Ernesto BERNAL-MIZRACHI - Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Brehm Center for Diabetes Research, University of Michigan, Ann Arbor, Michigan, United States
Publication Details: Diabetes (New York, N.Y.), Vol.59(10), pp.2390-2399
Publisher: American Diabetes Association
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Endocrinology, Diabetes & Metabolism
Language: English
Resource Type: Journal article
PMID: 20622167
PMCID: PMC3279560
Record Identifier: 991031615167702976