Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

Kunihiro Tsukasaki; Olivier Hermine; Ali Bazarbachi; Lee Ratner; Juan Carlos Ramos; William Harrington; Deirdre O’Mahony; John E Janik; Achiléa L Bittencourt; Graham P Taylor; Kazunari Yamaguchi; Atae Utsunomiya; Kensei Tobinai; Toshiki Watanabe

doi:10.1200/JCO.2008.18.2428

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Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

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Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

Kunihiro Tsukasaki, Olivier Hermine, Ali Bazarbachi, Lee Ratner, Juan Carlos Ramos, William Harrington, Deirdre O’Mahony, John E Janik, Achiléa L Bittencourt, Graham P Taylor, …

Journal of clinical oncology, Vol.27(3), pp.453-459

2009-01-20

DOI: https://doi.org/10.1200/JCO.2008.18.2428

PMCID: PMC2737379

PMID: 19064971

Abstract

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Adult T-cell leukemia-lymphoma (ATL) is a distinct peripheral T-lymphocytic malignancy associated with a retrovirus designated human T-cell lymphotropic virus type I (HTLV-1). The diversity in clinical features and prognosis of patients with this disease has led to its subclassification into the following four categories: acute, lymphoma, chronic, and smoldering types. The chronic and smoldering subtypes are considered indolent and are usually managed with watchful waiting until disease progression, analogous to the management of some patients with chronic lymphoid leukemia (CLL) or other indolent histology lymphomas. Patients with aggressive ATL generally have a poor prognosis because of multidrug resistance of malignant cells, a large tumor burden with multiorgan failure, hypercalcemia, and/or frequent infectious complications as a result of a profound T-cell immunodeficiency. Under the sponsorship of the 13th International Conference on Human Retrovirology: HTLV, a group of ATL researchers joined to form a consensus statement based on established data to define prognostic factors, clinical subclassifications, and treatment strategies. A set of response criteria specific for ATL reflecting a combination of those for lymphoma and CLL was proposed. Clinical subclassification is useful but is limited because of the diverse prognosis among each subtype. Molecular abnormalities within the host genome, such as tumor suppressor genes, may account for these diversities. A treatment strategy based on the clinical subclassification and prognostic factors is suggested, including watchful waiting approach, chemotherapy, antiviral therapy, allogeneic hematopoietic stem-cell transplantation (alloHSCT), and targeted therapies.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.1464 HTLV-1
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine

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Title: Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting
Creators: Kunihiro Tsukasaki - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Olivier Hermine - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Ali Bazarbachi - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Lee Ratner - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Juan Carlos Ramos - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
William Harrington - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Deirdre O’Mahony - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
John E Janik - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Achiléa L Bittencourt - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Graham P Taylor - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Kazunari Yamaguchi - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Atae Utsunomiya - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Kensei Tobinai - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Toshiki Watanabe - From the Nagasaki University, Nagasaki, Japan; Hospital Necker, University Paris V Rene Descartes and CNRS UMR 8147, Paris, France; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Washington University, St Louis, MO; National Cancer Institute, Bethesda, MD; Federal University of Bahia, Bahia, Brazil; Imperial College London, London, United Kingdom; National Institute of Infectious Diseases; National Cancer Center Hospital; Tokyo University, Tokyo; and Imamura Bun-in Hospital, Kagoshima, Japan
Publication Details: Journal of clinical oncology, Vol.27(3), pp.453-459
Publisher: American Society of Clinical Oncology
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Hematology/Oncology
Language: English
Resource Type: Journal article
PMID: 19064971
PMCID: PMC2737379
Record Identifier: 991031600023302976