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Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives
Journal article   Peer reviewed

Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern--synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

Ling He, He-Xi Chang, Ting-Chao Chou, Niramol Savaraj and C C Cheng
European journal of medicinal chemistry, Vol.38(1), pp.101-107
2003-01
DOI: https://doi.org/10.1016/S0223-5234(02)01420-4
PMID: 12593920

Abstract

Naphthalenes - chemistry Models, Chemical Antineoplastic Agents - chemical synthesis Humans HL-60 Cells - drug effects Indoles - chemical synthesis Cell Line, Tumor - drug effects Structure-Activity Relationship Quinolines - pharmacology Quinolines - chemical synthesis Drug Design Indoles - pharmacology Antineoplastic Agents - pharmacology Molecular Structure Drug Screening Assays, Antitumor
Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyelocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel.

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59 Times Cited - Web of Science

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
2 Chemistry
2.1 Synthesis
2.1.171 Multicomponent Reaction
Web Of Science research areas
Chemistry, Medicinal
ESI research areas
Chemistry

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