Designing a broad-spectrum integrative approach for cancer prevention and treatment

Keith I. Block; Charlotte Gyllenhaal; Leroy Lowe; Amedeo Amedei; A. R. M. Ruhul Amin; Amr Amin; Katia Aquilano; Jack Arbiser; Alexandra Arreola; Alla Arzumanyan; S. Salman Ashraf; Asfar S. Azmi; Fabian Benencia; Dipita Bhakta; Alan Bilsland; Anupam Bishayeen; Stacy W. Blain; Penny B. Block; Chandra S. Boosani; Thomas E. Carey; Amancio Carnero; Marianeve Carotenuto; Stephanie C. Casey; Mrinmay Chakrabarti; Rupesh Chaturvedi; Georgia Zhuo Chen; Helen Chenx; Sophie Chen; Yi Charlie Chen; Beom K. Choi; Maria Rosa Ciriolo; Helen M. Coley; Andrew R. Collins; Marisa Connell; Sarah Crawford; Colleen S. Curran; Charlotta Dabrosin; Giovanna Damia; Santanu Dasgupta; Ralph J. DeBerardinis; William K. Decker; Punita Dhawan; Anna Mae E. Diehl; Jin-Tang Dong; Q. Ping Dou; Janice E. Drew; Eyad Elkord; Bassel El-Rayes; Mark A. Feitelson; Dean W. Felsher; Lynnette R. Ferguson; Carmela Fimognari; Gary L. Firestone; Christian Frezza; Hiromasa Fujii; Mark M. Fuster; Daniele Generali; Alexandros G. Georgakilas; Frank Gieseler; Michael Gilbertson; Michelle F. Green; Brendan Grue; Gunjan Guha; Dorota Halicka; William G. Helferich; Petr Heneberg; Patricia Hentosh; Matthew D. Hirschey; Lorne J. Hofseth; Randall F. Holcombe; Kanya Honoki; Hsue-Yin Hsu; Gloria S. Huang; Lasse D. Jensen; Wen G. Jiang; Lee W. Jones; Phillip A. Karpowicz; W. Nicol Keith; Sid P. Kerkar; Gazala N. Khan; Mahin Khatami; Young H. Ko; Omer Kucuk; Rob J. Kulathinal; Nagi B. Kumar; Byoung S. Kwon; Anne Le; Michael A. Lea; Ho-Young Lee; Terry Lichtor; Liang-Tzung Lin; Jason W. Locasale; Bal L. Lokeshwar; Valter D. Longo; Costas A. Lyssiotis; Karen L. MacKenzie; Meenakshi Malhotra; Maria Marino; Maria L. Martinez-Chantar; Ander Matheu; Christopher Maxwell; Eoin McDonnell; Alan K. Meeker; Mahya Mehrmohamadi; Kapil Mehta; Gregory A. Michelotti; Ramzi M. Mohammad; Sulma I. Mohammed; D. James Morre; Irfana Muqbil; Vinayak Muralidhar; Michael P. Murphy; Ganji Purnachandra Nagaraju; Rita Nahta; Elena Niccolai; Somaira Nowsheen; Carolina Panis; Francesco Pantano; Virginia R. Parslow; Graham Pawelec; Peter L. Pedersen; Brad Poore; Deepak Poudyal; Satya Prakash; Mark Prince; Lizzia Raffaghello; Jeffrey C. Rathmell; W. Kimryn Rathmell; Swapan K. Ray; Joerg Reichrath; Sarallah Rezazadeh; Domenico Ribatti; Luigi Ricciardiello; R. Brooks Robey; Francis Rodier; H. P. Vasantha Rupasinghe; Gian Luigi Russo; Elizabeth P. Ryan; Abbas K. Samadi; Isidro Sanchez-Garcia; Andrew J. Sanders; Daniele Santini; Malancha Sarkar; Tetsuro Sasada; Neeraj K. Saxena; Rodney E. Shackelford; H. M. C. Shantha Kumara; Dipali Sharma; Dong M. Shin; David Sidransky; Markus David Siegelin; Emanuela Signori; Neetu Singh; Sharanya Sivanand; Daniel Sliva; Carl Smythe; Carmela Spagnuolo; Diana M. Stafforini; John Stagg; Pochi R. Subbarayan; Tabetha Sundin; Wamidh H. Talib; Sarah K. Thompson; Phuoc T. Tran; Hendrik Ungefroren; Matthew G. Vander Heiden; Vasundara Venkateswaran; Dass S. Vinay; Panagiotis J. Vlachostergios; Zongwei Wang; Kathryn E. Wellendx; Richard L. Whelan; Eddy S. Yang; Huanjie Yang; Xujuan Yang; Paul Yaswen; Clement Yedjou; Xin Yin; Jiyue Zhu; Massimo Zollo

doi:10.1016/j.semcancer.2015.09.007

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Designing a broad-spectrum integrative approach for cancer prevention and treatment

Journal article

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Peer reviewed

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Keith I. Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, A. R. M. Ruhul Amin, Amr Amin, Katia Aquilano, Jack Arbiser, Alexandra Arreola, Alla Arzumanyan, …

Seminars in cancer biology, Vol.35, pp.S276-S304

2015-12-01

DOI: https://doi.org/10.1016/j.semcancer.2015.09.007

PMID: 26590477

Abstract

Life Sciences & Biomedicine

Science & Technology

Oncology

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. (C) 2015 The Authors. Published by Elsevier Ltd.

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Citation topics: 1 Clinical & Life Sciences; 1.108 Molecular & Cell Biology - Cancer & Development; 1.108.591 Cancer Stem Cells
Web Of Science research areas: Oncology
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Title: Designing a broad-spectrum integrative approach for cancer prevention and treatment
Creators: Keith I. Block - Block Ctr Integrat Canc Treatment, Skokie, IL 60077 USA
Charlotte Gyllenhaal - Block Ctr Integrat Canc Treatment, Skokie, IL 60077 USA
Leroy Lowe - Getting Know Canc, Truro, NS, Canada
Amedeo Amedei - Univ Florence, Dept Expt & Clin Med, Florence, Italy
A. R. M. Ruhul Amin - Emory University
Amr Amin - United Arab Emirates University
Katia Aquilano - United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain, U Arab Emirates
Jack Arbiser - Atlanta Vet Adm Med Ctr, Atlanta, GA USA
Alexandra Arreola - Univ Roma Tor Vergata, Dept Biol, Rome, Italy
Alla Arzumanyan - Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
S. Salman Ashraf - United Arab Emirates University
Asfar S. Azmi - United Arab Emirates Univ, Coll Sci, Dept Chem, Al Ain, U Arab Emirates
Fabian Benencia - Wayne State Univ, Karmanos Canc Inst, Dept Oncol, Detroit, MI USA
Dipita Bhakta - Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA
Alan Bilsland - SASTRA Univ, Sch Chem & Bio Technol, Thanjavur, Tamil Nadu, India
Anupam Bishayeen - Univ Glasgow, Glasgow, Lanark, Scotland
Stacy W. Blain - Larkin Hlth Sci Inst, Coll Pharm, Dept Pharmaceut Sci, Miami, FL USA
Penny B. Block - Block Ctr Integrat Canc Treatment, Skokie, IL 60077 USA
Chandra S. Boosani - Suny Downstate Med Ctr, Dept Pediat, Brooklyn, NY USA
Thomas E. Carey - Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA
Amancio Carnero - CSIC, Inst Biomed Sevilla, Seville, Spain
Marianeve Carotenuto - Ctr Ingn Genet & Biotecnol Avanzate, Naples, Italy
Stephanie C. Casey - Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy
Mrinmay Chakrabarti - Stanford Univ, Div Oncol, Dept Pathol & Med, Stanford, CA 94305 USA
Rupesh Chaturvedi - Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC USA
Georgia Zhuo Chen
Helen Chenx - Jawaharlal Nehru University
Sophie Chen - Univ British Columbia, Dept Pediat, Michael Cuccione Childhood Canc Res Program, Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada
Yi Charlie Chen - Ovarian & Prostate Canc Res Lab, Guildford, Surrey, England
Beom K. Choi - Natl Canc Ctr, Div Canc Biol, Canc Immunol Branch, Goyang, Gyeonggi, South Korea
Maria Rosa Ciriolo - United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain, U Arab Emirates
Helen M. Coley - Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey, England
Andrew R. Collins - Univ Oslo, Fac Med, Dept Nutr, Oslo 3, Norway
Marisa Connell - Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India
Sarah Crawford - So Connecticut State Univ, Canc Biol Res Lab, New Haven, CT 06515 USA
Colleen S. Curran - Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA
Charlotta Dabrosin - Linkoping Univ, Dept Oncol, Linkoping, Sweden
Giovanna Damia - Ist Ric Farmacol Mario Negri, Ist Ricovero Cura Carattere Sci, Dept Oncol, Milan, Italy
Santanu Dasgupta - Univ Texas Hlth Sci Ctr Tyler, Dept Cellular & Mol Biol, Tyler, TX USA
Ralph J. DeBerardinis - Univ Texas SW Med Ctr Dallas, Childrens Med Ctr Res Inst, Dallas, TX 75390 USA
William K. Decker - Baylor College of Medicine
Punita Dhawan - Vanderbilt Univ, Sch Med, Div Surg Oncol, Dept Surg & Canc Biol, Nashville, TN 37212 USA
Anna Mae E. Diehl - Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
Jin-Tang Dong
Q. Ping Dou - United Arab Emirates Univ, Coll Sci, Dept Chem, Al Ain, U Arab Emirates
Janice E. Drew - Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen, Scotland
Eyad Elkord - United Arab Emirates Univ, Coll Med & Hlth Sci, Al Ain, U Arab Emirates
Bassel El-Rayes - Emory Univ, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
Mark A. Feitelson - Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Dean W. Felsher - Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy
Lynnette R. Ferguson - Univ Auckland, Discipline Nutr, Auckland 1, New Zealand
Carmela Fimognari - Univ Auckland, Auckland Canc Soc Res Ctr, Auckland 1, New Zealand
Gary L. Firestone - Univ Bologna, Dipartimento Sci Qualita Vita Alma Mater Studioru, Rimini, Italy
Christian Frezza - Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
Hiromasa Fujii - Univ Cambridge, Hutchison MRC Res Ctr, Med Res Council Canc Unit, Cambridge, England
Mark M. Fuster - Nara Med Univ, Dept Orthoped Surg, Kashihara, Nara 634, Japan
Daniele Generali - Univ Calif San Diego, Med & Res Serv, Vet Affairs San Diego Healthcare Syst, San Diego, CA 92103 USA
Alexandros G. Georgakilas - Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy
Frank Gieseler - Azienda Osped Ist Ospitalieri Cremona, Mol Therapy & Pharrnacogen Unit, Cremona, Italy
Michael Gilbertson - Natl Tech Univ Athens, Sch Appl Math & Phys Sci, Dept Phys, Athens, Greece
Michelle F. Green - Emmes
Brendan Grue - Getting Know Canc, Guelph, ON, Canada
Gunjan Guha - Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA
Dorota Halicka - Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC USA
William G. Helferich - Dalhousie Univ, Dept Environm Sci Microbiol & Immunol, Halifax, NS, Canada
Petr Heneberg - Charles Univ Prague, Fac Med 3, Prague, Czech Republic
Patricia Hentosh - Univ Illinois, Champaign, IL 61820 USA
Matthew D. Hirschey - Univ Hosp Schleswig Holstein, Dept Med 1, Lubeck, Germany
Lorne J. Hofseth
Randall F. Holcombe - Old Domin Univ, Sch Med Lab & Radiat Sci, Norfolk, VA USA
Kanya Honoki
Hsue-Yin Hsu - Univ S Carolina, Coll Pharm, Columbia, SC 29208 USA
Gloria S. Huang - Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
Lasse D. Jensen - Tzu Chi Univ, Dept Life Sci, Hualien, Taiwan
Wen G. Jiang - Cardiff Univ, Sch Med, Heath Pk, Cardiff, Wales
Lee W. Jones - Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
Phillip A. Karpowicz - Univ Windsor, Windsor, ON N9B 3P4, Canada
W. Nicol Keith - SASTRA Univ, Sch Chem & Bio Technol, Thanjavur, Tamil Nadu, India
Sid P. Kerkar - Mayo Clin, Lab Med & Pathol, Rochester, MN USA
Gazala N. Khan - Henry Ford Hosp, Detroit, MI 48202 USA
Mahin Khatami - Natl Inst Hlth, Natl Canc Inst, Inflammat & Canc Res, Bethesda, MD USA
Young H. Ko - Univ Maryland BioPark, Innovat Ctr, KoDiscovery, Baltimore, MD USA
Omer Kucuk
Rob J. Kulathinal - Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Nagi B. Kumar - University of Miami, UMMG Department of Public Health Sciences Research
Byoung S. Kwon - Natl Canc Ctr, Div Canc Biol, Canc Immunol Branch, Goyang, Gyeonggi, South Korea
Anne Le - Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD USA
Michael A. Lea - Rutgers State Univ, New Jersey Med Sch, Newark, NJ USA
Ho-Young Lee - Seoul Natl Univ, Coll Pharm, Seoul 151, South Korea
Terry Lichtor - Rush Univ, Med Ctr, Dept Neurosurg, Chicago, IL 60612 USA
Liang-Tzung Lin - Taipei Med Univ, Coll Med, Sch Med, Dept Microbiol & Immunol, Taipei, Taiwan
Jason W. Locasale - Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
Bal L. Lokeshwar - University of Miami, UMMG Department of Urology
Valter D. Longo - Univ So Calif, Div Biogerontol, Andrus Gerontol Ctr, Los Angeles, CA USA
Costas A. Lyssiotis - Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI USA
Karen L. MacKenzie - Childrens Canc Inst Australia, Kensington, NSW, Australia
Meenakshi Malhotra - McGill Univ, Dept Biomed Engn, Montreal, PQ, Canada
Maria Marino - Univ Rome Tre, Dept Sci, I-00146 Rome, Italy
Maria L. Martinez-Chantar - Technol Pk Bizkaia, Ctr Invest Biomed Red Enfermedades Hepat Digest, Metabol Unit, Bizkaia, Spain
Ander Matheu - Biodonostia Inst, Gipuzkoa, Spain
Christopher Maxwell - Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India
Eoin McDonnell - Univ Hosp Schleswig Holstein, Dept Med 1, Lubeck, Germany
Alan K. Meeker - Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
Mahya Mehrmohamadi - Cornell Univ, Dept Mol Biol & Genet, Field Genet Gen & Dev, Ithaca, NY USA
Kapil Mehta - Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
Gregory A. Michelotti - Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
Ramzi M. Mohammad - United Arab Emirates Univ, Coll Sci, Dept Chem, Al Ain, U Arab Emirates
Sulma I. Mohammed - Purdue Univ, Ctr Canc Res, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA
D. James Morre - Mor NuCo Inc, Purdue Res Pk, W Lafayette, IN USA
Irfana Muqbil - United Arab Emirates Univ, Coll Sci, Dept Chem, Al Ain, U Arab Emirates
Vinayak Muralidhar - Harvard Univ, Sch Med, Harvard MIT Div Hlth Sci & Technol, Boston, MA USA
Michael P. Murphy - MRC Mitochondrial Biol Unit, Cambridge, England
Ganji Purnachandra Nagaraju - Emory Univ, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA
Rita Nahta
Elena Niccolai - Univ Florence, Florence, Italy
Somaira Nowsheen - Mayo Clin, Mayo Med Sch, Mayo Grad Sch, Med Sci Training Program, Rochester, MN USA
Carolina Panis - State Univ West Parana, UNIOESTE, Lab Inflammatory Mediators, Parana, Brazil
Francesco Pantano - Univ Campus Bio Med, Dept Med Oncol, Rome, Italy
Virginia R. Parslow - Univ Auckland, Discipline Nutr, Auckland 1, New Zealand
Graham Pawelec - Univ Tubingen, Med Res Ctr, Tubingen, Germany
Peter L. Pedersen - Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Biol Chem & Oncol Member Large, Baltimore, MD USA
Brad Poore - Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD USA
Deepak Poudyal
Satya Prakash - McGill Univ, Dept Biomed Engn, Montreal, PQ, Canada
Mark Prince - Univ Michigan, Sch Med, Dept Otolaryngol Head & Neck, Ann Arbor, MI USA
Lizzia Raffaghello - Ist Giannina Gaslini, Lab Oncol, I-16148 Genoa, Italy
Jeffrey C. Rathmell - Univ Hosp Schleswig Holstein, Dept Med 1, Lubeck, Germany
W. Kimryn Rathmell - Univ Roma Tor Vergata, Dept Biol, Rome, Italy
Swapan K. Ray - Stanford Univ, Div Oncol, Dept Pathol & Med, Stanford, CA 94305 USA
Joerg Reichrath - Saarland Univ Hosp, Clin Dermatol Venerol & Allergol, Ctr Clin & Expt Photodermatol, Homburg, Germany
Sarallah Rezazadeh - Univ Rochester, Dept Biol, Rochester, NY 14627 USA
Domenico Ribatti - Univ Bari, Sch Med, Dept Basic Med Sci Neurosci & Sensory Organs, Bari, Italy
Luigi Ricciardiello - Natl Canc Inst Giovanni Paolo II, Bari, Italy
R. Brooks Robey - Univ Bologna, Dept Med & Surg Sci, Bologna, Italy
Francis Rodier - Geisel Sch Med Dartmouth, Hanover, NH USA
H. P. Vasantha Rupasinghe - Inst Canc Montreal, Montreal, PQ, Canada
Gian Luigi Russo - Univ Montreal, Dept Radiol, Radio Oncol & Med Nucl, Montreal, PQ, Canada
Elizabeth P. Ryan - University of Miami, Rosenstiel School
Abbas K. Samadi - Dalhousie Univ, Dept Pathol, Fac Med, Halifax, NS, Canada
Isidro Sanchez-Garcia - CNR, Inst Food Sci, Avellino, Italy
Andrew J. Sanders - Cardiff Univ, Sch Med, Heath Pk, Cardiff, Wales
Daniele Santini - Univ Campus Bio Med, Dept Med Oncol, Rome, Italy
Malancha Sarkar - University of Miami, A&S - Biology
Tetsuro Sasada - Sanus Biosci, San Diego, CA USA
Neeraj K. Saxena - Univ Salamanca, CSIC, Inst Biol Mol & Celular Canc, Expt Therapeut & Translat Oncol Program, E-37008 Salamanca, Spain
Rodney E. Shackelford (Author) - Univ Miami, Dept Biol, Miami, FL USA
H. M. C. Shantha Kumara - Theodore Roosevelt High School
Dipali Sharma - Kurume Univ, Sch Med, Dept Immunol, Kurume, Fukuoka 830, Japan
Dong M. Shin
David Sidransky - Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
Markus David Siegelin - Louisiana State Univ, Hlth Shreveport, Dept Pathol, Shreveport, LA 71105 USA
Emanuela Signori - Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
Neetu Singh - Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA
Sharanya Sivanand - Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY USA
Daniel Sliva - Inst Translat Pharmacol, Natl Res Council, Rome, Italy
Carl Smythe - Univ Sheffield, Dept Biomed Sci, Sheffield Canc Res Ctr, Sheffield S10 2TN, S Yorkshire, England
Carmela Spagnuolo - Univ Montreal, Dept Radiol, Radio Oncol & Med Nucl, Montreal, PQ, Canada
Diana M. Stafforini - Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA
John Stagg - Univ Utah, Dept Internal Med, Salt Lake City, UT USA
Pochi R. Subbarayan - Univ Montreal, Ctr Rech Ctr Hosp, Faculte Pharmacie, Inst Canc Montreal, Montreal, PQ, Canada
Tabetha Sundin (Contributor) - Univ Miami, Sch Med, Dept Med, Miami, FL USA
Wamidh H. Talib - Sentara Healthcare, Dept Mol Diagnost, Norfolk, VA USA
Sarah K. Thompson - Appl Sci Univ, Dept Clin Pharm & Therapeut, Amman, Jordan
Phuoc T. Tran - Royal Adelaide Hosp, Dept Surg, Adelaide, SA 5000, Australia
Hendrik Ungefroren - Azienda Osped Ist Ospitalieri Cremona, Mol Therapy & Pharrnacogen Unit, Cremona, Italy
Matthew G. Vander Heiden - MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
Vasundara Venkateswaran - Johns Hopkins Univ, Sch Med, Baltimore, MD USA
Dass S. Vinay - Tulane Univ, Hlth Sci Ctr, Dept Med, Sect Clin Immunol Allergy & Rheumatol, New Orleans, LA USA
Panagiotis J. Vlachostergios - Johns Hopkins Univ, Dept Radiat Oncol, Baltimore, MD USA
Zongwei Wang - Johns Hopkins Univ, Dept Mol Radiat Sci Oncol & Urol, Baltimore, MD USA
Kathryn E. Wellendx - Columbia University
Richard L. Whelan - St Lukes Roosevelt Hosp, Dept Surg, New York, NY 10025 USA
Eddy S. Yang - Univ Alabama Birmingham, Med Sch Birmingham, Dept Radiat Oncol, Birmingham, AL USA
Huanjie Yang - Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150006, Heilongjiang, Peoples R China
Xujuan Yang - Dalhousie Univ, Dept Environm Sci Microbiol & Immunol, Halifax, NS, Canada
Paul Yaswen - Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA USA
Clement Yedjou - Jackson State Univ, Dept Biol, Jackson, MS USA
Xin Yin - Nara Med Univ, Dept Orthoped Surg, Kashihara, Nara 634, Japan
Jiyue Zhu - Washington State Univ, Coll Pharm, Spokane, WA USA
Massimo Zollo - Ctr Ingn Genet & Biotecnol Avanzate, Naples, Italy
Publication Details: Seminars in cancer biology, Vol.35, pp.S276-S304
Publisher: Elsevier
Number of pages: 29
Grant note: HEALTH-F2-2008-201662 / European FP7-TuMIC G12MD007581 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) PI-0135-2010; PI-0306-2012 / Consejeria de Salud of the Junta de Andalucia; Junta de Andalucia Scottish Government's Rural and Environment Science and Analytical Services Division CPRIT National Cancer Institute, Pancreatic Cancer Action Network, Pew Charitable Trusts Svenska Sallskapet for Medicinsk Forskning Welsh Government A4B scheme United Soybean Board PON01-02388/1 2007-2013 / European National Funds BIO/SA06/13 / Junta de Castilla y Leon International Life Sciences Institute 10216; 13837 / AIRC; Fondazione AIRC per la ricerca sul cancro Alma Toorock Memorial for Cancer Research Huntsman Cancer Foundation Connecticut State University Harvard-MIT Health Sciences and Technology Research Assistantship Award IG15221 / Italian Association for Cancer Research (AIRC-Grant); Fondazione AIRC per la ricerca sul cancro CTSI-2013-P03 / University of Miami Clinical and Translational Science Institute (CTSI) Pilot Research Grant IG10636; 15403 / Italian Association for Cancer Research (AIRC); Fondazione AIRC per la ricerca sul cancro NIH Intramural Research Program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NRF-2005-0093837 / National Research Foundation R01CA028704 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Albert Hung Foundation Pfizer 311876 / European Community's Seventh Framework Program FP7 Bayer Pharmaceutical T32HL098062 / NIH/National Heart, Lung, and Blood Institute Training Grant NIH R01CA156776 / United States' Public Health Services Grants W81XVVH-11-1-0272; W81XWH-13-1-0182 / DoD; United States Department of Defense W81XWH-12-1-0515 / IDEA Award from the Department of Defense Aveo Pharmaceutical; Johnson & Johnson CCMP101-RD-031; CCMP102-RD-112 / Ministry of Health and Welfare; Ministry of Health, Labour and Welfare, Japan Children's Cancer Institute Australia NT13663-3/2012 / Internal Grant Agency of the Ministry of Health of the Czech Republic project 2012/712404 / Marie Curie CIG Grant 80028595 / Sol Goldman Pancreatic Cancer Research Fund Grant R01CA131294; R21 CA155686 / NIH NCI grants U01ES019458 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 16SV5536K / German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF); Federal Ministry of Education & Research (BMBF) American Diabetes Association Roche; Roche Holding 1030 / Terry Fox Research Institute Bristol Myers Squibb; Bristol-Myers Squibb 2012RFLX5011 / Scientific Research Foundation for the Returned Oversea Scholars, State Education Ministry and Scientific and Technological Innovation Project, Harbin FP7 259679 "IDEAL" / European Commission; European Commission Joint Research Centre Fong Family Foundation MOP114962; MOP125857 / Canadian Institute for Health Research; Canadian Institutes of Health Research (CIHR) 90047965 / Breast Cancer Research Foundation Grant SEEDS You Choose Awards MC_UU_12022/6 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 278570 / European Union Seventh Framework Programme (FP7) 17UB-8708 / California Breast Cancer Research Program NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P01AT003961 / National Center for Complementary & Integrative Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA PI12/00137; RTICC: RD12/0036/0028 / Spanish Ministry of Economy and Competitivity, ISCIII European Union; European Commission Swedish Research Society Kyowa Kirin 5P01CA073992 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) University of Italy Auckland Cancer Society Research Centre (ACSRC) Yorkshire Cancer Research Wellcome Trust, UK; Wellcome Trust P30AG028716-01 / National Institute of Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Carlos III Health Institute; Instituto de Salud Carlos III 2011-0017639; 2011-0030001 / Ministry of Science, ICT AMP; Future Planning (MSIP), Republic of Korea Duke University Molecular Cancer Biology T32 Training Grant FEDER; European Commission National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32-CA059365-19; 5T32-CA059365 / NIH/NCI training grants to Duke University 24590493 / Ministry of Education, Culture, Sports, Science and Technology, Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) R01HL107652 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Beatson Oncology Centre Fund Italian Ministry of Economy and Finance Project CAMPUS-QUARC, within program FESR Campania Region 90049125; NIHR21CA169757 / Lustgarten Fund Grant 5101-BX001517-02 / VA-BLRAMP;D Merit Review Grant Regione Campania L.R:N.5 K08NS083732 / National Institute of Health, NINDS Grant F31CA154080 / NIH NRSA Grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Cancer Society of New Zealand NCC-1310430-2 / National Cancer Center TMUTOP103005-4 / Ministry of Education of Taiwan; Ministry of Education, Taiwan R01AI110613 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) CA164095 / NIH Public Service Grant from the National Cancer Institute University Roma Tre MC-CIG-303514 / EU Marie Curie Reintegration Grant; European Commission Michael Cuccione Childhood Cancer Foundation Postdoctoral Fellowship NIH National Institute on Alcohol Abuse and Alcoholism (NIAAA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) OBC-134038 / Avon Foundation for Women Bayer Healthcare System G4T (Grants4Targets) Cinque per Mille dell'IRPEF-Finanziamento della Ricerca Sanitaria AM: CP10/00539; PI13/02277 / Feder funds; European Commission GRACE Charity, UK 15-03834Y; P301/12/1686 / Czech Science Foundation projects AR47901; R21CA188818; R15 CA137499-01; F32CA177139; P20RR016477; P20GM103434; R01CA170378; U54CA149145; U54CA143907; R01-HL107652; R01CA166348; R01GM071725; R01 CA109335-04A1; 109511R01CA151304CA168997 A11106131R03CA1711326 1P01AT003961RO1 CA100816P01AG034906 R01AG020642P01AG034906-01A1R01HL108006 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA V Foundation A1076535 / NIH/NIAID Grant; CGIAR Medical Research Council CCU-Program Grant on cancer metabolism; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01AG020642 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) C301/A14762 / University of Glasgow, Beatson Oncology Centre Fund, CRUK Elsa U. Pardee Foundation K01DK077137 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) PIE13/0004 / ISCIII; Instituto de Salud Carlos III National Research Foundation of Korea (NRF); National Research Foundation of Korea K01AT007324 / NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Complementary & Alternative Medicine MIS 379346 / Greek National funds through the Operational Program 'Educational and Lifelong Learning of the National Strategic Reference Framework (NSRF)-Research Funding Program THALES 15-32432A / Czech Health Research Council AZV project I01BX001517 / Veterans Affairs; US Department of Veterans Affairs Ovarian and Prostate Cancer Research Trust, UK 31S118 / UAEU Program for Advanced Research (UPAR) West Virginia Higher Education Policy Commission/Division of Science Research K08NS083732 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 13-20-23-SIEG / AACR-National Brain Tumor Society Career Development Award for Translational Brain Tumor Research National Science Foundation; National Science Foundation (NSF) MSH-136647; MOP 64308 / Canadian Institutes of Health; Canadian Institutes of Health Research (CIHR) 22624 / Fonds de Recherche Quebec Sante University of Glasgow National Research Foundation Auckland Cancer Society Pancreatic Cancer Action Network NIH NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K01AT007324 / NIH NCCAM Grant Shire Pharmaceuticals SAF2012-32810 / MICINN; Spanish Government; European Commission 122688-RSG-12-196-01-TBG / ACS Scholar award Swedish Research Council; European Commission United Arab Emirates University FEDER funds; European Commission K01DK077137; R03DK089130 / NIH NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Michael Cuccione Childhood Cancer Foundation Graduate Studentship National Sciences Engineering and Research Council Undergraduate Student Research Award in Canada UNCE 204015; PRVOUK P31/2012 / Charles University in Prague projects Breast Cancer Campaign, UK Gilead and Shire Pharmaceuticals Damon Runyon Cancer Research Foundation Sky Foundation Inc. Michigan AI076535 / NIH (NIAID) R01: Combination therapies for chronic HBV, liver disease, and cancer R01GM071725 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Cancer Prevention and Research Institute of Texas University of Texas Health Science Centre at Tyler, Elsa U. Pardee Foundation ES019458 / United States National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AR047901 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) CTS-6844; CTS-1848 / FEDER from Regional Development European Funds (European Union), Consejeria de Ciencia e Innovacion TF-13-20 / Terry Fox Foundation Grant Avon Foundation SR/FT/LS-063/2008 / Department of Science and Technology, New Delhi, India; Department of Science & Technology (India) Cancer Research Wales Basque Foundation for Science (IKERBASQUE) Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) 1R01CA20009; 5R01CAl27258-05; R21CA184788; NIH P30 CA22453; NCI RO1 28704 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) SKF-13-021 / Kimmel Translational Science Award MC_UU_12022/6 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission NIH NIAAA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) Novartis Pharmaceutical FP7-ENV-2011 / ARIMMORA project P20RR016477 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) NIH NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) COST Action CM1201 `Biomimetic Radical Chemistry' 11963 / Italian Association for Cancer research (AIRC) Grant IG; Fondazione AIRC per la ricerca sul cancro 61040055-10 / Tzu-Chi University of Taiwan R33 CA161873-02 / NIH NCI Grant ceh010010 / Natural Environment Research Council; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC) G1200MD007581 / National Institutes of Health through the RCMI-Center for Environmental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA American Cancer Society Italian Ministry of University; Ministry of Education, Universities and Research (MIUR) Terry Fox Foundation
Academic Unit: A&S - Biology; Miller School of Medicine
Language: English
Resource Type: Journal article
PMID: 26590477
Record Identifier: 991031706517702976