Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Meng-Meng Zhang; Na Liu; Yuan-Liang Zhang; Bowen Rong; Xiao-Lin Wang; Chun-Hui Xu; Yin-Yin Xie; Shuhong Shen; Jiang Zhu; Stephen D Nimer; Zhu Chen; Sai-Juan Chen; Robert G Roeder; Fei Lan; Lan Wang; Qiu-Hua Huang; Xiao-Jian Sun

doi:10.1038/s41375-019-0398-8

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Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Journal article

Open access

Peer reviewed

Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation

Meng-Meng Zhang, Na Liu, Yuan-Liang Zhang, Bowen Rong, Xiao-Lin Wang, Chun-Hui Xu, Yin-Yin Xie, Shuhong Shen, Jiang Zhu, Stephen D Nimer, …

Leukemia, Vol.33(7), pp.1822-1827

2019-07

DOI: https://doi.org/10.1038/s41375-019-0398-8

PMID: 30755707

Abstract

Translocation, Genetic

CCAAT-Enhancer-Binding Protein-alpha - metabolism

Oncogene Proteins, Fusion - metabolism

Leukemia - pathology

T-Cell Acute Lymphocytic Leukemia Protein 1 - genetics

Humans

Gene Expression Regulation, Neoplastic

Neoplasm Proteins - antagonists & inhibitors

Leukemia - metabolism

Neoplasm Proteins - metabolism

Oncogene Proteins, Fusion - chemistry

Basic Helix-Loop-Helix Transcription Factors - metabolism

Core Binding Factor Alpha 2 Subunit - chemistry

Biomarkers, Tumor - metabolism

RUNX1 Translocation Partner 1 Protein - genetics

Cell Differentiation

RUNX1 Translocation Partner 1 Protein - metabolism

Tumor Cells, Cultured

Neoplasm Proteins - genetics

Chromosomes, Human, Pair 21

Leukemia - genetics

Basic Helix-Loop-Helix Transcription Factors - genetics

Core Binding Factor Alpha 2 Subunit - metabolism

T-Cell Acute Lymphocytic Leukemia Protein 1 - metabolism

Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors

Chromosomes, Human, Pair 8

Inhibitor of Differentiation Protein 1 - metabolism

Xenograft Model Antitumor Assays

Animals

Oncogene Proteins, Fusion - genetics

CCAAT-Enhancer-Binding Protein-alpha - genetics

Inhibitor of Differentiation Protein 1 - genetics

Biomarkers, Tumor - genetics

Mice

Core Binding Factor Alpha 2 Subunit - genetics

RUNX1 Translocation Partner 1 Protein - chemistry

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.103 Blood Disorders; 1.103.155 Acute Myeloid Leukemia
Web Of Science research areas: Hematology; Oncology
ESI research areas: Clinical Medicine

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Details

Title: Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation
Creators: Meng-Meng Zhang - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Na Liu - CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Yuan-Liang Zhang - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Bowen Rong - Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Xiao-Lin Wang - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Chun-Hui Xu - CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
Yin-Yin Xie - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shuhong Shen - Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Jiang Zhu - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Stephen D Nimer - Department of Biochemistry and Molecular Biology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
Zhu Chen - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Sai-Juan Chen - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Robert G Roeder - Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA
Fei Lan - Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Lan Wang - CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. lwang@sibs.ac.cn
Qiu-Hua Huang - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hqh10632@rjh.com.cn
Xiao-Jian Sun - State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xjsun@sibs.ac.cn
Publication Details: Leukemia, Vol.33(7), pp.1822-1827
Grant note: R01 CA163086 / NCI NIH HHS R01 CA166835 / NCI NIH HHS R01 CA178765 / NCI NIH HHS
Academic Unit: Leadership Department; Miller School of Medicine; Sylvester Comprehensive Cancer Center
Language: English
Resource Type: Journal article
PMID: 30755707
Record Identifier: 991031599564002976