Abstract
In this retrospective observational study we developed and validated a clinically useful nomogram predicting intraoperative adverse events. The nomogram includes five variables: tumor size, RENAL nephrometry score, Charlson comorbidity index, tumor multifocality, and indication for partial nephrectomy. Analysis demonstrated that the nomogram is internally valid and reasonably accurate in predicting intraoperative adverse events.
Ability to predict the risk of intraoperative adverse events (IOAEs) for patients undergoing partial nephrectomy (PN) can be of great clinical significance.
To develop and internally validate a preoperative nomogram predicting IOAEs for robot-assisted PN (RAPN).
In this observational study, data for demographic, preoperative, and postoperative variables for patients who underwent RAPN were extracted from the Vattikuti Collective Quality Initiative (VCQI) database.
IOAEs were defined as the occurrence of intraoperative surgical complications, blood transfusion, or conversion to open surgery/radical nephrectomy. Backward stepwise logistic regression analysis was used to identify predictors of IOAEs. The nomogram was validated using bootstrapping, the area under the receiver operating characteristic curve (AUC), and the goodness of fit. Decision curve analysis (DCA) was used to determine the clinical utility of the model.
Among the 2114 patients in the study cohort, IOAEs were noted in 158 (7.5%). Multivariable analysis identified five variables as independent predictors of IOAEs: RENAL nephrometry score (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.02–1.25); clinical tumor size (OR 1.01, 95% CI 1.001–1.024); PN indication as absolute versus elective (OR 3.9, 95% CI 2.6–5.7) and relative versus elective (OR 4.2, 95% CI 2.2–8); Charlson comorbidity index (OR 1.17, 95% CI 1.05–1.30); and multifocal tumors (OR 8.8, 95% CI 5.4–14.1). A nomogram was developed using these five variables. The model was internally valid on bootstrapping and goodness of fit. The AUC estimated was 0.76 (95% CI 0.72–0.80). DCA revealed that the model was clinically useful at threshold probabilities >5%. Limitations include the lack of external validation and selection bias.
We developed and internally validated a nomogram predicting IOAEs during RAPN.
We developed a preoperative model than can predict complications that might occur during robotic surgery for partial removal of a kidney. Tests showed that our model is fairly accurate and it could be useful in identifying patients with kidney cancer for whom this type of surgery is suitable.
