Development of a microsatellite genetic map spanning 5q31–q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H Yamaoka; Carol A Westbrook; Marcy C Speer; James M Gilchrist; Ethylin W Jabs; Elizabeth G Schweins; Jeffrey M Stajich; Perry C Gaskell; Allen D Roses; Margaret A Pericak-Vance

doi:10.1016/0960-8966(94)90086-8

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Development of a microsatellite genetic map spanning 5q31–q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Journal article

Peer reviewed

Development of a microsatellite genetic map spanning 5q31–q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H Yamaoka, Carol A Westbrook, Marcy C Speer, James M Gilchrist, Ethylin W Jabs, Elizabeth G Schweins, Jeffrey M Stajich, Perry C Gaskell, Allen D Roses and Margaret A Pericak-Vance

Neuromuscular disorders : NMD, Vol.4(5), pp.471-475

1994

DOI: https://doi.org/10.1016/0960-8966(94)90086-8

PMID: 7881291

Abstract

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22–31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31–33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.255 Musculoskeletal Disorders; 1.255.628 Duchenne Muscular Dystrophy
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior

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Title: Development of a microsatellite genetic map spanning 5q31–q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9
Creators: Larry H Yamaoka - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
Carol A Westbrook - Department of Medicine, University of Chicago, Chicago, Illinois, U.S.A
Marcy C Speer - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
James M Gilchrist - Rhode Island Hospital and Brown University, Providence, Rhode Island, U.S.A
Ethylin W Jabs - The Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A
Elizabeth G Schweins - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
Jeffrey M Stajich - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
Perry C Gaskell - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
Allen D Roses - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
Margaret A Pericak-Vance - Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, U.S.A
Publication Details: Neuromuscular disorders : NMD, Vol.4(5), pp.471-475
Publisher: Elsevier B.V
Academic Unit: Miller School of Medicine; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 7881291
Record Identifier: 991031560453302976