Abstract
Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.
- Title
- Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer
- Creators
- Ajeya Nandi - University of PennsylvaniaRahul Debnath - University of PennsylvaniaAnupma Nayak - University of PennsylvaniaTsun Ki Jerrick To - University of PennsylvaniaGatha Thacker - University of PennsylvaniaMegan Reilly - University of PennsylvaniaSanjeev Gumber - Emory UniversityIlias Karagounis - University of PennsylvaniaNing Li - University of PennsylvaniaChristopher J Lengner - University of PennsylvaniaMalay Haldar - University of PennsylvaniaAlana L Welm - Huntsman Cancer InstituteAndres M Blanco - University of PennsylvaniaChristoforos Thomas - University of PennsylvaniaRumela Chakrabarti - University of Pennsylvania
- Publication Details
- Cancer research (Chicago, Ill.), Vol.82(20), pp.3718-3733
- Grant note
- R01 CA237243 / NCI NIH HHS U54 CA224076 / NCI NIH HHS
- Academic Unit
- Miller School of Medicine; UMMG Department of Surgery; UMMG Dept of Surgery - Div of Surgical Oncology
- Language
- English
- Resource Type
- Journal article
- PMID
- 36007109
- Record Identifier
- 991032796093602976