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Does obesity-induced τ phosphorylation tip the scale toward dementia?
Journal article   Open access

Does obesity-induced τ phosphorylation tip the scale toward dementia?

T.F. Gendron, Y.-J. Zhang and L. Petrucelli
Diabetes, Vol.62(5), pp.1365-1366
2013
DOI: https://doi.org/10.2337/db12-1784
PMID: 23613550

Abstract

Animals Diet, High-Fat Hippocampus Insulin Resistance Male Obesity tau Proteins Tauopathies advanced glycation end product cytokine glucose glycogen synthase kinase 3beta insulin insulin receptor substrate 1 tau protein cognitive defect cytokine production dementia disease association disease severity dyslipidemia gene mutation glucose blood level glucose tolerance human hyperglycemia hypertension insulin resistance insulinemia memory disorder microvascular ischemia neurofibrillary tangle non insulin dependent diabetes mellitus nonhuman note obesity oxidative stress priority journal protein expression protein function protein phosphorylation risk reduction signal transduction tauopathy world health organization
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url
https://doi.org/10.2337/db12-1784View
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