Effect of Somatostatin on TSH Levels in Non-Toxic Sporadic Goiter

J Varea; M Paredes; G Garces; C Ochoa; C Avila; M. J Coloma; R Briones; A. M Comaru-Schally; A. V Schally

doi:10.1055/s-2007-1004989

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Effect of Somatostatin on TSH Levels in Non-Toxic Sporadic Goiter

Journal article

Peer reviewed

Effect of Somatostatin on TSH Levels in Non-Toxic Sporadic Goiter

J Varea, M Paredes, G Garces, C Ochoa, C Avila, M. J Coloma, R Briones, A. M Comaru-Schally and A. V Schally

Hormone and metabolic research, Vol.22(12), pp.627-631

1990-12

DOI: https://doi.org/10.1055/s-2007-1004989

PMID: 1981767

Abstract

Clinical

Summary Somatostatin (SS-14; growth hormone-release inhibiting hormone) was infused into eight patients with non-toxic sporadic goiter and into eleven normal control subjects. Each patient was given 150 μg of Somatostatin as an intravenous bolus and 350 μg by infusion over a period of 60 minutes. Somatostatin did not lower the basal TSH levels as compared to the pre-infusion levels in this type of goiter, but produced a decrease in the TSH response to TRH during and after the infusion.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.195 Neuroendocrine & Intestinal Disorders; 1.195.565 Neuroendocrine Tumors
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Biology & Biochemistry

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Details

Title: Effect of Somatostatin on TSH Levels in Non-Toxic Sporadic Goiter
Creators: J Varea - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
M Paredes - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
G Garces - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
C Ochoa - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
C Avila - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
M. J Coloma - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
R Briones - Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, and Ciencia Foundation for the Study of Man and Nature, Quito, Ecuador
A. M Comaru-Schally - Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louisiana, U. S. A
A. V Schally - Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louisiana, U. S. A
Publication Details: Hormone and metabolic research, Vol.22(12), pp.627-631
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 1981767
Record Identifier: 991031613555202976