Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

Adam C Naj; Gyungah Jun; Christiane Reitz; Brian W Kunkle; William Perry; Yo Son Park; Gary W Beecham; Ruchita A Rajbhandary; Kara L Hamilton-Nelson; Li-San Wang; John S K Kauwe; Matthew J Huentelman; Amanda J Myers; Thomas D Bird; Bradley F Boeve; Clinton T Baldwin; Gail P Jarvik; Paul K Crane; Ekaterina Rogaeva; M Michael Barmada; F Yesim Demirci; Carlos Cruchaga; Patricia L Kramer; Nilufer Ertekin-Taner; John Hardy; Neill R Graff-Radford; Robert C Green; Eric B Larson; Peter H St George-Hyslop; Joseph D Buxbaum; Denis A Evans; Julie A Schneider; Kathryn L Lunetta; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; Philip L De Jager; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Eden R Martin; Jonathan L Haines; Richard P Mayeux; Lindsay A Farrer; Gerard D Schellenberg; Margaret A Pericak-Vance; Marilyn S Albert; Roger L Albin; Liana G Apostolova; Steven E Arnold; Robert Barber; Lisa L Barnes; Thomas G Beach; James T Becker; Duane Beekly; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Laura B Cantwell; Chuanhai Cao; Chris S Carlson; Regina M Carney; Minerva M Carrasquillo; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; David H Cribbs; Elizabeth A Crocco; Charles DeCarli; Steven T DeKosky; Malcolm Dick; Dennis W Dickson; Ranjan Duara; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; Joel H Kramer; Frank M LaFerla; James J Lah; James B Leverenz; Allan I Levey; Ge Li; Andrew P Lieberman; Chiao-Feng Lin; Oscar L Lopez; Constantine G Lyketsos; Wendy J Mack; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Jill R Murrell; John M Olichney; Vernon S Pankratz; Joseph E Parisi; Henry L Paulson; Elaine Peskind; Ronald C Petersen; Aimee Pierce; Wayne W Poon; Huntington Potter; Joseph F Quinn; Ashok Raj; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Howard J Rosen; Roger N Rosenberg; Mary Sano; Lon S Schneider; William W Seeley; Amanda G Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; Tricia A Thornton-Wells; John Q Trojanowski; Juan C Troncoso; Otto Valladares; Vivianna M Van Deerlin; Linda J Van Eldik; Badri N Vardarajan; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Sarah Wishnek; Randall L Woltjer; Clinton B Wright; Steven G Younkin; Chang-En Yu; Lei Yu

doi:10.1001/jamaneurol.2014.1491

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Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

Journal article

Open access

Peer reviewed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

Adam C Naj, Gyungah Jun, Christiane Reitz, Brian W Kunkle, William Perry, Yo Son Park, Gary W Beecham, Ruchita A Rajbhandary, Kara L Hamilton-Nelson, Li-San Wang, …

JAMA neurology, Vol.71(11), pp.1394-1404

2014-11

DOI: https://doi.org/10.1001/jamaneurol.2014.1491

PMID: 25199842

Abstract

Genetic Predisposition to Disease

Genome-Wide Association Study

Prospective Studies

Humans

Middle Aged

Risk Factors

Genetic Loci - genetics

Genotype

Male

Age of Onset

Aged, 80 and over

Polymorphism, Single Nucleotide - genetics

Adult

Alzheimer Disease - epidemiology

Female

Aged

Alzheimer Disease - genetics

Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants. To investigate the effects of known Alzheimer disease risk loci in modifying AAO and to estimate their cumulative effect on AAO variation using data from genome-wide association studies in the Alzheimer Disease Genetics Consortium. The Alzheimer Disease Genetics Consortium comprises 14 case-control, prospective, and family-based data sets with data on 9162 participants of white race/ethnicity with Alzheimer disease occurring after age 60 years who also had complete AAO information, gathered between 1989 and 2011 at multiple sites by participating studies. Data on genotyped or imputed single-nucleotide polymorphisms most significantly associated with risk at 10 confirmed LOAD loci were examined in linear modeling of AAO, and individual data set results were combined using a random-effects, inverse variance-weighted meta-analysis approach to determine whether they contribute to variation in AAO. Aggregate effects of all risk loci on AAO were examined in a burden analysis using genotype scores weighted by risk effect sizes. Age at disease onset abstracted from medical records among participants with LOAD diagnosed per standard criteria. Analysis confirmed the association of APOE with earlier AAO (P = 3.3 × 10(-96)), with associations in CR1 (rs6701713, P = 7.2 × 10(-4)), BIN1 (rs7561528, P = 4.8 × 10(-4)), and PICALM (rs561655, P = 2.2 × 10(-3)) reaching statistical significance (P < .005). Risk alleles individually reduced AAO by 3 to 6 months. Burden analyses demonstrated that APOE contributes to 3.7% of the variation in AAO (R(2) = 0.256) over baseline (R(2) = 0.221), whereas the other 9 loci together contribute to 2.2% of the variation (R(2) = 0.242). We confirmed an association of APOE (OMIM 107741) variants with AAO among affected participants with LOAD and observed novel associations of CR1 (OMIM 120620), BIN1 (OMIM 601248), and PICALM (OMIM 603025) with AAO. In contrast to earlier hypothetical modeling, we show that the combined effects of Alzheimer disease risk variants on AAO are on the scale of, but do not exceed, the APOE effect. While the aggregate effects of risk loci on AAO may be significant, additional genetic contributions to AAO are individually likely to be small.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Disease
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior

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Title: Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study
Creators: Adam C Naj - Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia
Gyungah Jun - Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts
Christiane Reitz - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York7Gertrude H. Sergievsky Center, Columbia University, New York, New York8Department of Neurology, Columbia University, New York, New
Brian W Kunkle - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida
William Perry - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida
Yo Son Park - The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida
Gary W Beecham - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida
Ruchita A Rajbhandary - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida
Kara L Hamilton-Nelson - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida
Li-San Wang - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
John S K Kauwe - Department of Biology, Brigham Young University, Provo, Utah
Matthew J Huentelman - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona
Amanda J Myers - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida
Thomas D Bird - Department of Neurology, University of Washington, Seattle15Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington
Bradley F Boeve - Department of Neurology, Mayo Clinic, Rochester, Minnesota
Clinton T Baldwin - Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts
Gail P Jarvik - Department of Genome Sciences, University of Washington, Seattle18Division of Medical Genetics, Department of Medicine, University of Washington, Seattle
Paul K Crane - Department of Medicine, University of Washington, Seattle
Ekaterina Rogaeva - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
M Michael Barmada - Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania
F Yesim Demirci - Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania
Carlos Cruchaga - Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri
Patricia L Kramer - Department of Neurology, Oregon Health & Science University, Portland24Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland
Nilufer Ertekin-Taner - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida
John Hardy - Institute of Neurology, University College London, London, England
Neill R Graff-Radford - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida26Department of Neurology, Mayo Clinic, Jacksonville, Florida
Robert C Green - Division of Genetics, Department of Medicine, and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
Eric B Larson - Department of Medicine, University of Washington, Seattle29Group Health Research Institute, Group Health Cooperative, Seattle, Washington
Peter H St George-Hyslop - Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada30Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, England
Joseph D Buxbaum - Department of Neuroscience, Mount Sinai School of Medicine, New York, New York32Department of Psychiatry, Mount Sinai School of Medicine, New York, New York33Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York
Denis A Evans - Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois
Julie A Schneider - Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois36Neuropathology, Department of Pathology, Rush University Medical Center, Chicago, Illinois
Kathryn L Lunetta - Department of Biostatistics, Boston University, Boston, Massachusetts
M Ilyas Kamboh - Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania37Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania
Andrew J Saykin - Department of Medical and Molecular Genetics, Indiana University, Indianapolis39Department of Radiology and Imaging Sciences, Indiana University, Indianapolis
Eric M Reiman - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona40Arizona Alzheimer's Consortium, Phoenix41Department of Psychiatry, University of Arizona, Phoenix42Banner Alzheimer's Institute, Phoenix, Arizona
Philip L De Jager - Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts44Program in Medical and Population Genetics, Broad Ins
David A Bennett - Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois45Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois
John C Morris - Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri47Department of Neurology, Washington University in St Louis, St Louis, Missouri
Thomas J Montine - Department of Pathology, University of Washington, Seattle
Alison M Goate - Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, School of Medicine, Washington University in St Louis, St Louis, Missouri
Deborah Blacker - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts50Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston
Debby W Tsuang - Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington51Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle
Hakon Hakonarson - Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Walter A Kukull - Department of Epidemiology, University of Washington, Seattle
Tatiana M Foroud - Department of Medical and Molecular Genetics, Indiana University, Indianapolis
Eden R Martin - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida
Jonathan L Haines - Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee55Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
Richard P Mayeux - Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York57Gertrude H. Sergievsky Center, Columbia University, New York, New York58Department of Neurology, Columbia University, New York, New York
Lindsay A Farrer - Genetics Program, Department of Medicine, Boston University, Boston, Massachusetts4Department of Biostatistics, Boston University, Boston, Massachusetts5Department of Ophthalmology, Boston University, Boston, Massachusetts59Department of Epidemiology, Bos
Gerard D Schellenberg - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
Margaret A Pericak-Vance - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida
Marilyn S Albert - Department of Neurology, Johns Hopkins University, Baltimore, Maryland
Roger L Albin - Department of Neurology, University of Michigan, Ann Arbor63Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan64Michigan Alzheimer Disease Center, Ann Arbor
Liana G Apostolova - Department of Neurology, University of California Los Angeles, Los Angeles
Steven E Arnold - Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia
Robert Barber - Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth
Lisa L Barnes - Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois68Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois
Thomas G Beach - Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona
James T Becker - Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Duane Beekly - National Alzheimer's Coordinating Center, University of Washington, Seattle
Eileen H Bigio - Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois73Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois
James D Bowen - Swedish Medical Center, Seattle, Washington
Adam Boxer - Department of Neurology, University of California San Francisco, San Francisco
James R Burke - Department of Medicine, Duke University, Durham, North Carolina
Nigel J Cairns - Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri
Laura B Cantwell - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
Chuanhai Cao - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa
Chris S Carlson - Fred Hutchinson Cancer Research Center, Seattle, Washington
Regina M Carney - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida
Minerva M Carrasquillo - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
Steven L Carroll - Department of Pathology, University of Alabama at Birmingham, Birmingham
Helena C Chui - Department of Neurology, University of Southern California, Los Angeles
David G Clark - Department of Neurology, University of Alabama at Birmingham, Birmingham
Jason Corneveaux - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona
David H Cribbs - Department of Neurology, University of California Irvine, Irvine
Elizabeth A Crocco - Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida
Charles DeCarli - Department of Neurology, University of California Davis, Sacramento
Steven T DeKosky - University of Virginia School of Medicine, Charlottesville
Malcolm Dick - Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine
Dennis W Dickson - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
Ranjan Duara - Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida
Kelley M Faber - Department of Medical and Molecular Genetics, Indiana University, Indianapolis
Kenneth B Fallon - Department of Pathology, University of Alabama at Birmingham, Birmingham
Martin R Farlow - Department of Neurology, Indiana University, Indianapolis
Steven Ferris - Department of Psychiatry, New York University, New York
Matthew P Frosch - C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown
Douglas R Galasko - Department of Neurosciences, University of California San Diego, La Jolla
Mary Ganguli - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
Marla Gearing - Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia93Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia
Daniel H Geschwind - Neurogenetics Program, University of California Los Angeles, Los Angeles
Bernardino Ghetti - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis
John R Gilbert - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida9The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida
Jonathan D Glass - Department of Neurology, Emory University, Atlanta, Georgia
John H Growdon - Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston
Ronald L Hamilton - Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania
Lindy E Harrell - Department of Neurology, University of Alabama at Birmingham, Birmingham
Elizabeth Head - Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington
Lawrence S Honig - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York
Christine M Hulette - Department of Pathology, Duke University, Durham, North Carolina
Bradley T Hyman - Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston
Gregory A Jicha - Sanders-Brown Center on Aging, Department Neurology, University of Kentucky, Lexington
Lee-Way Jin - Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento
Anna Karydas - Department of Neurology, University of California San Francisco, San Francisco
Jeffrey A Kaye - Department of Neurology, Oregon Health & Science University, Portland103Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon
Ronald Kim - Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine
Edward H Koo - Department of Neurosciences, University of California San Diego, La Jolla
Neil W Kowall - Department of Neurology, Boston University, Boston, Massachusetts105Department of Pathology, Boston University, Boston, Massachusetts
Joel H Kramer - Department of Neuropsychology, University of California San Francisco, San Francisco
Frank M LaFerla - Department of Neurobiology and Behavior, University of California Irvine, Irvine
James J Lah - Department of Neurology, Emory University, Atlanta, Georgia
James B Leverenz - Department of Pathology, University of Washington, Seattle
Allan I Levey - Department of Neurology, Emory University, Atlanta, Georgia
Ge Li - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle
Andrew P Lieberman - Department of Pathology, University of Michigan, Ann Arbor
Chiao-Feng Lin - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
Oscar L Lopez - Alheimer Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania
Constantine G Lyketsos - Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland
Wendy J Mack - Department of Preventive Medicine, University of Southern California, Los Angeles
Frank Martiniuk - Department of Medicine - Pulmonary, New York University, New York
Deborah C Mash - Department of Neurology, University of Miami, Miami, Florida
Eliezer Masliah - Department of Neurosciences, University of California San Diego, La Jolla113Department of Pathology, University of California San Diego, La Jolla
Wayne C McCormick - Department of Medicine, University of Washington, Seattle
Susan M McCurry - School of Nursing Northwest Research Group on Aging, University of Washington, Seattle
Andrew N McDavid - Fred Hutchinson Cancer Research Center, Seattle, Washington
Ann C McKee - Department of Neurology, Boston University, Boston, Massachusetts105Department of Pathology, Boston University, Boston, Massachusetts
Marsel Mesulam - Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois115Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Bruce L Miller - Department of Neurology, University of California San Francisco, San Francisco
Carol A Miller - Department of Pathology, University of Southern California, Los Angeles
Joshua W Miller - Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento
Jill R Murrell - Department of Medical and Molecular Genetics, Indiana University, Indianapolis95Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis
John M Olichney - Department of Neurology, University of California Davis, Sacramento
Vernon S Pankratz - Department of Biostatistics, Mayo Clinic, Rochester, Minnesota
Joseph E Parisi - Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota119Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
Henry L Paulson - Department of Neurology, University of Michigan, Ann Arbor
Elaine Peskind - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle
Ronald C Petersen - Department of Neurology, Mayo Clinic, Rochester, Minnesota
Aimee Pierce - Department of Neurology, University of California Irvine, Irvine
Wayne W Poon - Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine
Huntington Potter - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa
Joseph F Quinn - Department of Neurology, Oregon Health & Science University, Portland
Ashok Raj - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa
Murray Raskind - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle
Barry Reisberg - Department of Psychiatry, New York University, New York120Alzheimer's Disease Center, New York University, New York
John M Ringman - Department of Neurology, University of California Los Angeles, Los Angeles
Erik D Roberson - Department of Neurology, University of Alabama at Birmingham, Birmingham
Howard J Rosen - Department of Neurology, University of California San Francisco, San Francisco
Roger N Rosenberg - Department of Neurology, University of Texas Southwestern, Dallas
Mary Sano - Department of Psychiatry, Mount Sinai School of Medicine, New York, New York
Lon S Schneider - Department of Neurology, University of Southern California, Los Angeles122Department of Psychiatry, University of Southern California, Los Angeles
William W Seeley - Department of Neurology, University of California San Francisco, San Francisco
Amanda G Smith - USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa
Joshua A Sonnen - Department of Pathology, University of Washington, Seattle
Salvatore Spina - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis
Robert A Stern - Department of Neurology, Boston University, Boston, Massachusetts
Rudolph E Tanzi - Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston
Tricia A Thornton-Wells - Vanderbilit Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee
John Q Trojanowski - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
Juan C Troncoso - Department of Pathology, Johns Hopkins University, Baltimore, Maryland
Otto Valladares - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
Vivianna M Van Deerlin - Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia
Linda J Van Eldik - Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington
Badri N Vardarajan - Department of Neurology, Columbia University, New York, New York
Harry V Vinters - Department of Neurology, University of California Los Angeles, Los Angeles125Department of Pathology & Laboratory Medicine, University of California Los Angeles, Los Angeles
Jean Paul Vonsattel - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York
Sandra Weintraub - Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois127Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Kathleen A Welsh-Bohmer - Department of Medicine, Duke University, Durham, North Carolina128Department of Psychiatry & Behavioral Sciences, Duke University, Durham, North Carolina
Jennifer Williamson - Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York
Sarah Wishnek - John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida
Randall L Woltjer - Department of Pathology, Oregon Health & Science University, Portland
Clinton B Wright - Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida
Steven G Younkin - Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
Chang-En Yu - Department of Medicine, University of Washington, Seattle
Lei Yu - Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois
Publication Details: JAMA neurology, Vol.71(11), pp.1394-1404
Publisher: United States
Grant note: P30 AG062421 / NIA NIH HHS P30 AG028377 / NIA NIH HHS P50 NS039764 / NINDS NIH HHS P50 AG005144 / NIA NIH HHS R01 AG027944 / NIA NIH HHS R01 AG030146 / NIA NIH HHS UO1 AG06781 / NIA NIH HHS P50 MH060451 / NIMH NIH HHS R01 AG034504 / NIA NIH HHS P50 AG008702 / NIA NIH HHS P50 AG023501 / NIA NIH HHS R37 AG015473 / NIA NIH HHS P01 AG010491 / NIA NIH HHS P50 AG005681 / NIA NIH HHS P30 AG008017 / NIA NIH HHS R01 AG031581 / NIA NIH HHS R01 AG019085 / NIA NIH HHS 5R01AG012101 / NIA NIH HHS P01 AG03991 / NIA NIH HHS R01 AG030653 / NIA NIH HHS 5R01AG022374 / NIA NIH HHS R01 AG041797 / NIA NIH HHS R01 AG021547 / NIA NIH HHS P50 AG016573 / NIA NIH HHS P01 AG019724 / NIA NIH HHS HG004610 / NHGRI NIH HHS U24 AG026390 / NIA NIH HHS UL1RR02777 / NCRR NIH HHS K01 AG030514 / NIA NIH HHS R01 MH080295 / NIMH NIH HHS P50 AG005134 / NIA NIH HHS R01 NS080820 / NINDS NIH HHS P50 AG005128 / NIA NIH HHS MH60451 / NIMH NIH HHS P50 AG016575 / NIA NIH HHS NS39764 / NINDS NIH HHS RF1 AG015819 / NIA NIH HHS R01 CA129769 / NCI NIH HHS R01 AG035137 / NIA NIH HHS P30 AG08051 / NIA NIH HHS P30 AG010129 / NIA NIH HHS R01 AG020688 / NIA NIH HHS AG041718 / NIA NIH HHS R01 AG022374 / NIA NIH HHS R01 AG026916 / NIA NIH HHS P50 AG005142 / NIA NIH HHS R01 NS059873 / NINDS NIH HHS P30 AG010124 / NIA NIH HHS U24 AG026395 / NIA NIH HHS 100140 / Wellcome Trust R01 AG17917 / NIA NIH HHS U01 AG016976 / NIA NIH HHS U24 AG021886 / NIA NIH HHS R01 AG017917 / NIA NIH HHS P30 AG008051 / NIA NIH HHS 081864 / Wellcome Trust U01 AG032984 / NIA NIH HHS P50 AG016574 / NIA NIH HHS U01 AG006781 / NIA NIH HHS P50 AG008671 / NIA NIH HHS R01 AG019757 / NIA NIH HHS P30 ES013508 / NIEHS NIH HHS R01 AG30146 / NIA NIH HHS RC2 AG036528 / NIA NIH HHS MO1RR00096 / NCRR NIH HHS R01 AG041232 / NIA NIH HHS Medical Research Council Howard Hughes Medical Institute R01 AG041718 / NIA NIH HHS P50 AG005131 / NIA NIH HHS M01 RR000096 / NCRR NIH HHS P30 AG019610 / NIA NIH HHS P50 AG016576 / NIA NIH HHS P01 AG002219 / NIA NIH HHS P50 AG005136 / NIA NIH HHS U01 AG024904 / NIA NIH HHS Canadian Institutes of Health Research 1R01AG035137 / NIA NIH HHS R01AG33193 / NIA NIH HHS 5R01AG013616 / NIA NIH HHS AG021547 / NIA NIH HHS P50 AG005146 / NIA NIH HHS UL1 TR000135 / NCATS NIH HHS AG030653 / NIA NIH HHS RC2 AG036535 / NIA NIH HHS P50 AG016582 / NIA NIH HHS P50 AG016570 / NIA NIH HHS U01 HG004610 / NHGRI NIH HHS P30 AG010161 / NIA NIH HHS P30 AG013854 / NIA NIH HHS AG027944 / NIA NIH HHS R01 AG012101 / NIA NIH HHS G-0907 / Parkinson's UK R01 AG017173 / NIA NIH HHS R01 AG015819 / NIA NIH HHS AG034504 / NIA NIH HHS 1RC2AG036502 / NIA NIH HHS U01 AG10483 / NIA NIH HHS AG05128 / NIA NIH HHS R01 AG15819 / NIA NIH HHS R01 AG033193 / NIA NIH HHS AG010491 / NIA NIH HHS AG019757 / NIA NIH HHS UL1 TR001108 / NCATS NIH HHS U01 AG010483 / NIA NIH HHS 089703 / Wellcome Trust P30 AG028383 / NIA NIH HHS P30 AG012300 / NIA NIH HHS P30 AG010133 / NIA NIH HHS P50 AG005133 / NIA NIH HHS R01 AG013616 / NIA NIH HHS U24 AG056270 / NIA NIH HHS P50 AG025688 / NIA NIH HHS P01 AG003991 / NIA NIH HHS P30 AG013846 / NIA NIH HHS R01 AG025259 / NIA NIH HHS AG025688 / NIA NIH HHS P50 AG005138 / NIA NIH HHS P30AG10133 / NIA NIH HHS UL1 RR029893 / NCRR NIH HHS P50 AG016577 / NIA NIH HHS R01 AG026390 / NIA NIH HHS RC2 AG036502 / NIA NIH HHS
Academic Unit: Cell Biology Research; Miller School of Medicine; UMMG Department of Neurology; UMMG Dept of Psychiatry & Behavioral Sciences; John P. Hussman Institute for Human Genomics; UMMG Dept of Human Genetics (Dr. John T. Macdonald Foundation)
Language: English
Resource Type: Journal article
PMID: 25199842
Record Identifier: 991031561019402976