Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge

Danilo R Casimiro; Kara Cox; Aimin Tang; Kara J Sykes; Meizhen Feng; Fubao Wang; Andrew Bett; William A Schleif; Xiaoping Liang; Jessica Flynn; Timothy W Tobery; Keith Wilson; Adam Finnefrock; Lingyi Huang; Salvatore Vitelli; Jing Lin; Deepa Patel; Mary-Ellen Davies; Gwendolyn J Heidecker; Daniel C Freed; Sheri Dubey; David H O'Connor; David I Watkins; Zhi-Qiang Zhang; John W Shiver

doi:10.1128/JVI.00969-09

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Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge

Journal article

Open access

Peer reviewed

Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge

Danilo R Casimiro, Kara Cox, Aimin Tang, Kara J Sykes, Meizhen Feng, Fubao Wang, Andrew Bett, William A Schleif, Xiaoping Liang, Jessica Flynn, …

Journal of virology, Vol.84(6), pp.2996-3003

2010-03

DOI: https://doi.org/10.1128/JVI.00969-09

PMCID: PMC2826028

PMID: 20042509

Abstract

Vaccines and Antiviral Agents

The prophylactic efficacies of several multivalent replication-incompetent adenovirus serotype 5 (Ad5) vaccines were examined in rhesus macaques using an intrarectal high-dose simian immunodeficiency virus SIVmac239 challenge model. Cohorts of Mamu-A*01 + /B*17 − Indian rhesus macaques were immunized with one of several combinations of Ad5 vectors expressing Gag, Pol, Nef, and Env gp140; for comparison, a Mamu-A*01 + cohort was immunized using the Ad5 vector alone. There was no sign of immunological interference between antigens in the immunized animals. In general, expansion of the antigen breadth resulted in more favorable virological outcomes. In particular, the order of efficacy trended as follows: Gag/Pol/Nef/Env ≈ Gag/Pol > Gag ≈ Gag/Pol/Nef > Nef. However, the precision in ranking the vaccines based on the study results may be limited by the cohort size, and as such, may warrant additional testing. The implications of these results in light of the recent discouraging results of the phase IIb study of the trivalent Ad5 HIV-1 vaccine are discussed.

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Virology
ESI research areas: Microbiology

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Title: Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge
Creators: Danilo R Casimiro - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Kara Cox - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Aimin Tang - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Kara J Sykes - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Meizhen Feng - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Fubao Wang - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Andrew Bett - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
William A Schleif - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Xiaoping Liang - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Jessica Flynn - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Timothy W Tobery - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Keith Wilson - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Adam Finnefrock - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Lingyi Huang - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Salvatore Vitelli - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Jing Lin - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Deepa Patel - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Mary-Ellen Davies - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Gwendolyn J Heidecker - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Daniel C Freed - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Sheri Dubey - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
David H O'Connor - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
David I Watkins - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Zhi-Qiang Zhang - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
John W Shiver - Department of Vaccines Basic Research, Merck Research Laboratories, Merck & Co., West Point, Pennsylvania 19486
Publication Details: Journal of virology, Vol.84(6), pp.2996-3003
Publisher: American Society for Microbiology (ASM)
Academic Unit: UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 20042509
PMCID: PMC2826028
Record Identifier: 991031598536502976