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Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)
Journal article

Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)

Musleh M Muthana, Jingyao Qu, Yanhong Li, Lei Zhang, Hai Yu, Li Ding, Hamed Malekan and Xi Chen
Chemical communications (Cambridge, England), Vol.48(21), pp.2728-2730
2012-03-11
DOI: https://doi.org/10.1039/c2cc17577k
PMID: 22306833

Abstract

Uridine Diphosphate Glucose - biosynthesis Galactokinase - metabolism Uridine Diphosphate Galactose - chemistry Uridine Diphosphate Glucose - chemistry Pasteurella multocida - enzymology Uridine Diphosphate Sugars - biosynthesis Bifidobacterium - enzymology Inorganic Pyrophosphatase - metabolism UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism Uridine Diphosphate Galactose - biosynthesis Uridine Diphosphate Sugars - chemistry
A promiscuous UDP-sugar pyrophosphorylase (BLUSP) was cloned from Bifidobacterium longum strain ATCC55813 and used efficiently with a Pasteurella multocida inorganic pyrophosphatase (PmPpA) with or without a monosaccharide 1-kinase for one-pot multienzyme synthesis of UDP-galactose, UDP-glucose, UDP-mannose, and their derivatives. Further chemical diversification of a UDP-mannose derivative resulted in the formation of UDP-N-acetylmannosamine.

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
2 Chemistry
2.1 Synthesis
2.1.522 Thioglycosides
Web Of Science research areas
Chemistry, Multidisciplinary
ESI research areas
Chemistry

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