Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel

Stephen M Graham; Tahmeed Ahmed; Farhana Amanullah; Renee Browning; Vicky Cardenas; Martina Casenghi; Luis E Cuevas; Marianne Gale; Robert P Gie; Malgosia Grzemska; Ed Handelsman; Mark Hatherill; Anneke C Hesseling; Patrick Jean-Philippe; Beate Kampmann; Sushil Kumar Kabra; Christian Lienhardt; Jennifer Lighter-Fisher; Shabir Madhi; Mamodikoe Makhene; Ben J Marais; David F McNeeley; Heather Menzies; Charles Mitchell; Surbhi Modi; Lynne Mofenson; Philippa Musoke; Sharon Nachman; Clydette Powell; Mona Rigaud; Vanessa Rouzier; Jeffrey R Starke; Soumya Swaminathan; Claire Wingfield

doi:10.1093/infdis/jis008

Back

Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel

Journal article

Open access

Peer reviewed

Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel

Stephen M Graham, Tahmeed Ahmed, Farhana Amanullah, Renee Browning, Vicky Cardenas, Martina Casenghi, Luis E Cuevas, Marianne Gale, Robert P Gie, Malgosia Grzemska, …

The Journal of infectious diseases, Vol.205(Suppl 2), pp.S199-S208

2012-05-15

DOI: https://doi.org/10.1093/infdis/jis008

PMCID: PMC3334506

PMID: 22448023

Abstract

Main

There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis . A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis.

Files and links (1)

url

https://doi.org/10.1093/infdis/jis008View

Published (Version of record) Open

Metrics

8 Record Views

252 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.194 Tuberculosis & Leprosy; 1.194.273 Mycobacterium Tuberculosis
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology
ESI research areas: Immunology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Details

Title: Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel
Creators: Stephen M Graham - Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Childrens
Tahmeed Ahmed - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Farhana Amanullah - The Indus Hospital, Karachi, Pakistan
Renee Browning - Henry Jackson Foundation–Maternal Adolescent Pediatric Research Branch, Division of AIDS, National Institute of Allergyand Infectious Diseases, National Institutes of Health, Bethesda
Vicky Cardenas - Aeras, Rockville, Maryland
Martina Casenghi - Medecins sans Frontières, Geneva, Switzerland
Luis E Cuevas - School of Tropical Medicine, University of Liverpool,United Kingdom
Marianne Gale - Medecins sans Frontières, Sydney, Australia
Robert P Gie - Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
Malgosia Grzemska - Stop TB Partnership, World Health Organization, Geneva, Switzerland
Ed Handelsman - Maternal Adolescent Pediatric Research Branch, Division of AIDS, National Institute of Allergy
Mark Hatherill - South African Tuberculosis Vaccine Initiative, School of Child and Adolescent Health, University of Cape Town
Anneke C Hesseling - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
Patrick Jean-Philippe - Henry Jackson Foundation–Maternal Adolescent Pediatric Research Branch, Division of AIDS, National Institute of Allergyand Infectious Diseases, National Institutes of Health, Bethesda
Beate Kampmann - Department of Paediatrics, Imperial College, London, United Kingdom
Sushil Kumar Kabra - All India Institute of Medical Sciences, New Delhi
Christian Lienhardt - Stop TB Partnership, World Health Organization, Geneva, Switzerland
Jennifer Lighter-Fisher - New York University School of Medicine, New York, New York
Shabir Madhi - National Institute for Communicable Diseases, National Health Laboratory Services, Johannesburg, South Africa
Mamodikoe Makhene - Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Ben J Marais - Children’s Hospital Westmead, University of Sydney, Australia
David F McNeeley - Medical Service Corporation International, Arlington,Virginia
Heather Menzies - International Research and Programs Branch, Divisionof Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
Charles Mitchell - University of Miami Miller School of Medicine, Miami, Florida
Surbhi Modi - Maternal and Child Health Branch, Division of Global HIV/AIDS, Centers for Disease Control and Prevention, Atlanta, Georgia
Lynne Mofenson - Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland
Philippa Musoke - Makerere University–Johns Hopkins University Research Collaboration, Kampala, Uganda
Sharon Nachman - State University of New York School of Medicine at Stony Brook
Clydette Powell - Division of Infectious Disease, Office of Health, Infectious Disease, and Nutrition Bureau for Global Health, US Agency for International Development, Washington, DC
Mona Rigaud - New York University School of Medicine, New York, New York
Vanessa Rouzier - GHESKIO Centers, Port au Prince, Haiti
Jeffrey R Starke - Department of Pediatrics, Baylor College of Medicine, Houston, Texas
Soumya Swaminathan - National Institute for Research in Tuberculosis (formerly Tuberculosis Research Centre), Chennai, India
Claire Wingfield - Treatment Action Group, New York, New York
Publication Details: The Journal of infectious diseases, Vol.205(Suppl 2), pp.S199-S208
Publisher: Oxford University Press
Academic Unit: Miller School of Medicine; UMMG Department of Pediatrics; UMMG Dept of Pediatrics - Infectious Diseases
Language: English
Resource Type: Journal article
PMID: 22448023
PMCID: PMC3334506
Record Identifier: 991031562687002976