Exceptional response to FOLFIRINOX in a patient with pancreatic cancer and a germline RAD51C mutation

Sofia Palacio; Terri Pollack; Rachel Silva-Smith; Daniel A Sussman; Peter J Hosein

doi:10.21037/jgo.2018.03.11

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Exceptional response to FOLFIRINOX in a patient with pancreatic cancer and a germline RAD51C mutation

Journal article

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Exceptional response to FOLFIRINOX in a patient with pancreatic cancer and a germline RAD51C mutation

Sofia Palacio, Terri Pollack, Rachel Silva-Smith, Daniel A Sussman and Peter J Hosein

Journal of gastrointestinal oncology, Vol.9(4), pp.E19-E22

2018-08

DOI: https://doi.org/10.21037/jgo.2018.03.11

PMCID: PMC6087861

PMID: 30151275

Abstract

Pancreatic adenocarcinoma

oxaliplatin

RAD51C

Pancreatic cancer is projected to become the second leading cause of cancer death in the United States by 2030. Deleterious germline mutations can contribute to pancreatic cancer susceptibility. Herein we report a case of a patient with metastatic pancreatic adenocarcinoma to the lung and liver who was found to have a deleterious germline mutation in who had a remarkable response to chemotherapy with FOLFIRINOX, a platinum-containing regimen.

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Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.597 BRCA1
Web Of Science research areas: Gastroenterology & Hepatology; Oncology
ESI research areas: Clinical Medicine

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Details

Title: Exceptional response to FOLFIRINOX in a patient with pancreatic cancer and a germline RAD51C mutation
Creators: Sofia Palacio - Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, USA
Terri Pollack - Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, USA
Rachel Silva-Smith - Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, USA
Daniel A Sussman - Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, USA
Peter J Hosein - Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, USA
Publication Details: Journal of gastrointestinal oncology, Vol.9(4), pp.E19-E22
Publisher: China
Academic Unit: Miller School of Medicine; UMMG Dept of Medicine - Hematology/Oncology; UMMG Dept of Medicine - Gastroenterology
Language: English
Resource Type: Journal article
PMID: 30151275
PMCID: PMC6087861
Record Identifier: 991031561734502976