Exon-intron organization, expression, and chromosomal localization of the human motilin gene

H Yano; Y Seino; J Fujita; Y Yamada; N Inagaki; J Takeda; G.I Bell; R.L Eddy; Y.-S Fan; M.G Byers; T.B Shows; H Imura

doi:10.1016/0014-5793(89)80633-7

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Exon-intron organization, expression, and chromosomal localization of the human motilin gene

Journal article

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Exon-intron organization, expression, and chromosomal localization of the human motilin gene

H Yano, Y Seino, J Fujita, Y Yamada, N Inagaki, J Takeda, G.I Bell, R.L Eddy, Y.-S Fan, M.G Byers, …

FEBS letters, Vol.249(2), pp.248-252

1989

DOI: https://doi.org/10.1016/0014-5793(89)80633-7

PMID: 2737284

Abstract

Chromosome 6

Duodenum, Stomach, Human

Motilin gene

The human motilin gene has been isolated and characterized. The gene spans about 9 kilobase pairs (kb) and the 0.7 kb motilin mRNA is encoded by five exons. The 22-amino-acid motilin sequence is encoded by exons 2 and 3. The human motilin gene was mapped to the p21.2→p21.3 region of chromosome 6 by hybridization of the cloned cDNA to DNAs from a panel of reduced human-mouse somatic cell hybrids and by in situ hybridization to human prometaphase chromosomes. RNA blotting using RNA prepared from various regions of the human gastrointestinal tract revealed high levels of motilin mRNA in duodenum and lower levels in the antrum of the stomach; motilin mRNA could not be detected by this procedure in the esophagus, cardia of the stomach, descending colon or gallbladder.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.95 Gastrointestinal & Esophageal Diseases; 1.95.723 Irritable Bowel Syndrome
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ESI research areas: Biology & Biochemistry

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Details

Title: Exon-intron organization, expression, and chromosomal localization of the human motilin gene
Creators: H Yano
Y Seino - Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, Kyoto 606, Japan
J Fujita
Y Yamada
N Inagaki
J Takeda - Division of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, Kyoto 606, Japan
G.I Bell - Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biology and of Medicine, The University of Chicago, Chicago,IL 60637 U.S.A
R.L Eddy - Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY 14263, USA
Y.-S Fan - Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY 14263, USA
M.G Byers - Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY 14263, USA
T.B Shows - Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY 14263, USA
H Imura
Publication Details: FEBS letters, Vol.249(2), pp.248-252
Publisher: Elsevier B.V
Academic Unit: Miller School of Medicine; UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 2737284
Record Identifier: 991031614450602976