Abstract
Background:
Rates of type II endometrial cancers (EC) are increasing in the United States, especially in minority women. The purpose of this project was to examine a primarily minority and low socioeconomic status patient population in a public hospital to identify risk factors associated with the finding of type II histology in endometrial biopsies (EMBs).
Materials and Methods:
A retrospective chart review was performed of patients who underwent an EMB between 2010 and 2016. Included patients were postmenopausal women older than 50 years with biopsy-proven EC. Basic demographic data were analyzed, along with indication for EMB and ultrasound findings. Statistics were completed using analysis of variance and logistic regression with significance set at
p
< 0.05.
Results:
Four hundred sixty-one EMB results were reviewed. Around 17.4% (
n
= 80) resulted in a diagnosis of EC, with 45% (
n
= 36) being type II histology. Average age was 62.5 (standard deviation [SD] = 7.63), and the majority (64%) were Hispanic. Type II malignancies were diagnosed in 17% of Caucasians, 41% of Hispanics, and 61% of blacks/Haitians (
p
= 0.03). Factors associated with type II tumors in univariable models included older age (odds ratio [OR] 1.10 [confidence interval; CI 1.03–1.18],
p
= 0.007), black/Haitian (vs. Caucasian) race (OR 8.75 [CI 0.86–88.70],
p
= 0.066), obesity (OR 0.39 [0.15–0.98],
p
= 0.044), and number of years since menopause (OR 1.06 [CI 1.01–1.12],
p
= 0.027), although none remained independently predictive in the multivariable analysis.
Conclusion:
This minority population of postmenopausal women with EC had a greater prevalence of type II histologies. Understanding this pattern may be helpful in expediting the workup for abnormal symptoms in these women and prompt a higher level of suspicion for EC.
