From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia

Salvador M Guinjoan; Delfina de Achával; Mirta F Villarreal; Valeria Abusamra; Charles B Nemeroff

doi:10.1176/appi.neuropsych.14120377

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From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia

Journal article

Peer reviewed

From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia

Salvador M Guinjoan, Delfina de Achával, Mirta F Villarreal, Valeria Abusamra and Charles B Nemeroff

The journal of neuropsychiatry and clinical neurosciences, Vol.27(4), pp.254-261

2015

DOI: https://doi.org/10.1176/appi.neuropsych.14120377

PMID: 26067439

Abstract

Neuropsychological Tests

Schizophrenia - physiopathology

Social Behavior

Social Perception

Humans

Facial Expression

Schizophrenic Psychology

Nerve Net - physiopathology

Emotions

Cerebral Cortex - physiopathology

Schizophrenia is characterized by profound deficits in social competence and functioning, independent from active psychotic symptoms at different stages of the disease. Social deficits in schizophrenia are clinically well characterized, but their neurobiological underpinnings are undetermined. This article reviews recent evidence supporting heritable deficits in a circuit necessary for appropriate naming of emotions and mental states in others, centered at the temporoparietal junction of the nondominant hemisphere. The clinical implications of this model are discussed, including the potential use of rehabilitation techniques oriented to recognition and naming of emotions and mental states as a necessary step for social rehabilitation.

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.21 Psychiatry; 1.21.24 Schizophrenia
Web Of Science research areas: Clinical Neurology; Neurosciences; Psychiatry
ESI research areas: Neuroscience & Behavior

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Details

Title: From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia
Creators: Salvador M Guinjoan - From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN)
Delfina de Achával - From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN)
Mirta F Villarreal - From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN)
Valeria Abusamra - From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN)
Charles B Nemeroff - From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN)
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.27(4), pp.254-261
Publisher: United States
Academic Unit: UMMG Dept of Psychiatry & Behavioral Sciences
Language: English
Resource Type: Journal article
PMID: 26067439
Record Identifier: 991031577144502976