Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile

Chen Qiu; Bianca Maceo Heilman; Jari Kaipio; Paul Donaldson; Ehsan Vaghefi

doi:10.1364/BOE.8.004947

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Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile

Chen Qiu, Bianca Maceo Heilman, Jari Kaipio, Paul Donaldson and Ehsan Vaghefi

Biomedical optics express, Vol.8(11), pp.4947-4964

2017-11-01

DOI: https://doi.org/10.1364/BOE.8.004947

PMCID: PMC5695943

PMID: 29188093

Abstract

(170.0110) Imaging systems

(110.2760) Gradient-index lenses

(140.0140) Lasers and laser optics

Measuring the lens gradient refractive index (GRIN) accurately and reliably has proven an extremely challenging technical problem. A fully automated laser ray tracing (LRT) system was built to address this issue. The LRT system captures images of multiple laser projections before and after traversing through an ex vivo lens. These LRT images, combined with accurate measurements of the lens geometry, are used to calculate the lens GRIN profile. Mathematically, this is an ill-conditioned problem; hence, it is essential to apply biologically relevant constraints to produce a feasible solution. The lens GRIN measurements were compared with previously published data. Our GRIN retrieval algorithm produces fast and accurate measurements of the lens GRIN profile. Experiments to study the optics of physiologically perturbed lenses are the future direction of this research.

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Citation topics: 1 Clinical & Life Sciences; 1.36 Ophthalmology; 1.36.813 Myopia
Web Of Science research areas: Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging
ESI research areas: Biology & Biochemistry

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Details

Title: Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile
Creators: Chen Qiu - Department of Physiology, School of Medical Sciences, University of Auckland
Bianca Maceo Heilman - Department of Physiology, School of Medical Sciences, University of Auckland
Jari Kaipio - Faculty of Science, Department of Mathematics, University of Auckland
Paul Donaldson - Department of Physiology, School of Medical Sciences, University of Auckland
Ehsan Vaghefi - School of Optometry and Vision Science, University of Auckland
Publication Details: Biomedical optics express, Vol.8(11), pp.4947-4964
Publisher: Optical Society of America
Grant note: Whitaker International Scholar Award 3700559; 3707089 / New Zealand Optometric Vision Research Foundation (NZOVRF) Royal Society of New Zealand 3707893 / Maurice and Phyllis Paykel Trust (MPPT) 3706540 / New Zealand Royal Society Marsden project
Academic Unit: College of Engineering; CoE - Biomedical Engineering
Language: English
Resource Type: Journal article
PMID: 29188093
PMCID: PMC5695943
Record Identifier: 991031598409202976