Functional p85α gene is required for normal murine fetal erythropoiesis

Hannah Huddleston; Bailin Tan; Feng-Chun Yang; Hilary White; Mary Jo Wenning; Attilio Orazi; Mervin C Yoder; Reuben Kapur; David A Ingram

doi:10.1182/blood-2002-10-3245

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Functional p85α gene is required for normal murine fetal erythropoiesis

Journal article

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Functional p85α gene is required for normal murine fetal erythropoiesis

Hannah Huddleston, Bailin Tan, Feng-Chun Yang, Hilary White, Mary Jo Wenning, Attilio Orazi, Mervin C Yoder, Reuben Kapur and David A Ingram

Blood, Vol.102(1), pp.142-145

2003-07-01

DOI: https://doi.org/10.1182/blood-2002-10-3245

PMID: 12623844

Abstract

Abstract In vitro studies suggest that activation of class IA phosphatidylinositol 3 (PI-3) kinase is necessary for normal erythroid cell development. However, when class IA PI-3 kinase–deficient mice were generated by a targeted deletion of the p85α regulatory subunit, fetal erythropoiesis was reportedly unaffected. Given the discrepancies between these studies, we performed a more detailed in vivo analysis of class IA PI-3 kinase–deficient embryos. Day-14.5 p85α-/- embryos are pale with a marked reduction of mature erythrocytes in their peripheral blood. Further, the absolute number and frequency of both early (erythroid burst-forming unit [BFU-E]) and late erythroid progenitors (erythroid colony-forming unit [CFU-E]) are reduced in p85α-/- fetal livers compared with wild-type controls, which is associated with reduced proliferation. Taken together, these data establish an important role for p85α and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver. (Blood. 2003;102:142-145)

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Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.1030 Erythropoietin
Web Of Science research areas: Hematology
ESI research areas: Clinical Medicine

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Title: Functional p85α gene is required for normal murine fetal erythropoiesis
Creators: Hannah Huddleston - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Bailin Tan - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Feng-Chun Yang - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Hilary White - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Mary Jo Wenning - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Attilio Orazi - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Mervin C Yoder - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Reuben Kapur - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
David A Ingram - From the Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis; and the Department of Hematology/Pathology, Indiana University School of Medicine, Indianapolis
Publication Details: Blood, Vol.102(1), pp.142-145
Language: English
Resource Type: Journal article
PMID: 12623844
Record Identifier: 991031613374102976