Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression

Jonah B Sacha; Chungwon Chung; Eva G Rakasz; Sean P Spencer; Anna K Jonas; Alexander T Bean; Wonhee Lee; Benjamin J Burwitz; Jason J Stephany; John T Loffredo; David B Allison; Sama Adnan; Akihiko Hoji; Nancy A Wilson; Thomas C Friedrich; Jeffrey D Lifson; Otto O Yang; David I Watkins

doi:10.4049/jimmunol.178.5.2746

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Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression

Journal article

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Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression

Jonah B Sacha, Chungwon Chung, Eva G Rakasz, Sean P Spencer, Anna K Jonas, Alexander T Bean, Wonhee Lee, Benjamin J Burwitz, Jason J Stephany, John T Loffredo, …

The Journal of immunology (1950), Vol.178(5), pp.2746-2754

2007-03-01

DOI: https://doi.org/10.4049/jimmunol.178.5.2746

PMCID: PMC4520734

PMID: 17312117

Abstract

CD8 + T cells are a key focus of vaccine development efforts for HIV. However, there is no clear consensus as to which of the nine HIV proteins should be used for vaccination. The early proteins Tat, Rev, and Nef may be better CD8 + T cell targets than the late-expressed structural proteins Gag, Pol, and Env. In this study, we show that Gag-specific CD8 + T cells recognize infected CD4 + T lymphocytes as early as 2 h postinfection, before proviral DNA integration, viral protein synthesis, and Nef-mediated MHC class I down-regulation. Additionally, the number of Gag epitopes recognized by CD8 + T cells was significantly associated with lower viremia ( p = 0.0017) in SIV-infected rhesus macaques. These results suggest that HIV vaccines should focus CD8 + T cell responses on Gag.

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV-1
Web Of Science research areas: Immunology
ESI research areas: Immunology

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Title: Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression
Creators: Jonah B Sacha - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Chungwon Chung - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Eva G Rakasz - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Sean P Spencer - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Anna K Jonas - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Alexander T Bean - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Wonhee Lee - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Benjamin J Burwitz - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Jason J Stephany - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
John T Loffredo - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
David B Allison - Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294
Sama Adnan - AIDS Institute and Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095
Akihiko Hoji - AIDS Institute and Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095
Nancy A Wilson - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Thomas C Friedrich - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Jeffrey D Lifson - AIDS Vaccine Program, Science Applications International Corp. National Cancer Institute, Frederick, MD 21702
Otto O Yang - AIDS Institute and Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095
David I Watkins - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715
Publication Details: The Journal of immunology (1950), Vol.178(5), pp.2746-2754
Academic Unit: UMMG Department of Pathology
Language: English
Resource Type: Journal article
PMID: 17312117
PMCID: PMC4520734
Record Identifier: 991031600472602976